USP47

USP47
Identifikatori
Aliasi	USP47
Vanjski ID-jevi	OMIM: 614460 MGI: 1922246 HomoloGene: 9929 GeneCards: USP47
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek)[1] Bend 11p15.3 Početak 11,841,423 bp[1] Kraj 11,959,323 bp[1]
Lokacija gena (miš) Hrom. Hromosom 7 (miš)[2] Bend 7|7 F1 Početak 111,622,711 bp[2] Kraj 111,710,868 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • WD40-repeat domain binding • GO:0070122 peptidase activity • hydrolase activity • cysteine-type peptidase activity • thiol-dependent deubiquitinase • GO:0001948, GO:0016582 vezivanje za proteine • GO:1904265 deubiquitinase activity • cysteine-type endopeptidase activity Ćelijska komponenta • citoplazma • SCF ubiquitin ligase complex • nukleoplazma • citosol Biološki proces • ubiquitin-dependent protein catabolic process • Proteoliza • negative regulation of apoptotic process • cellular response to UV • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage • GO:0100026 Popravka DNK • positive regulation of cell growth • monoubiquitinated protein deubiquitination • base-excision repair • negative regulation of G2/M transition of mitotic cell cycle • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • cellular response to DNA damage stimulus • protein deubiquitination • positive regulation of canonical Wnt signaling pathway • regulation of protein stability Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	55031	74996
Ensembl	ENSG00000170242	ENSMUSG00000059263
UniProt	Q96K76	Q8BY87
RefSeq (mRNK)	NM_001282659 NM_017944 NM_001330208	NM_133758 NM_177249 NM_001357952
RefSeq (bjelančevina)	NP_001269588 NP_001317137 NP_060414 NP_001359020 NP_001359021 NP_001359022 NP_001359023 NP_001359024 NP_001359025 NP_001359026 NP_001359027 NP_001359028 NP_001359029 NP_001359030 NP_001359031 NP_001359032	NP_598519 NP_796223 NP_001344881 NP_001390423
Lokacija (UCSC)	Chr 11: 11.84 – 11.96 Mb	Chr 7: 111.62 – 111.71 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Ubikvitinska karboksil-terminalna hidrolaza 47 je enzim koji je kod ljudi kodiran genom USP47.^[5][6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.375 aminokiselina, а molekulska težina 157.311 Da.^[7]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MVPGEENQLV		PKEDVFWRCR		QNIFDEMKKK		FLQIENAAEE		PRVLCIIQDT
TNSKTVNERI		TLNLPASTPV		RKLFEDVANK		VGYINGTFDL		VWGNGINTAD
MAPLDHTSDK		SLLDANFEPG		KKNFLHLTDK		DGEQPQILLE		DSSAGEDSVH
DRFIGPLPRE		GSGGSTSDYV		SQSYSYSSIL		NKSETGYVGL		VNQAMTCYLN
SLLQTLFMTP		EFRNALYKWE		FEESEEDPVT		SIPYQLQRLF		VLLQTSKKRA
IETTDVTRSF		GWDSSEAWQQ		HDVQELCRVM		FDALEQKWKQ		TEQADLINEL
YQGKLKDYVR		CLECGYEGWR		IDTYLDIPLV		IRPYGSSQAF		ASVEEALHAF
IQPEILDGPN		QYFCERCKKK		CDARKGLRFL		HFPYLLTLQL		KRFDFDYTTM
HRIKLNDRMT		FPEELDMSTF		IDVEDEKSPQ		TESCTDSGAE		NEGSCHSDQM
SNDFSNDDGV		DEGICLETNS		GTEKISKSGL		EKNSLIYELF		SVMVHSGSAA
GGHYYACIKS		FSDEQWYSFN		DQHVSRITQE		DIKKTHGGSS		GSRGYYSSAF
ASSTNAYMLI		YRLKDPARNA		KFLEVDEYPE		HIKNLVQKER		ELEEQEKRQR
EIERNTCKIK		LFCLHPTKQV		MMENKLEVHK		DKTLKEAVEM		AYKMMDLEEV
IPLDCCRLVK		YDEFHDYLER		SYEGEEDTPM		GLLLGGVKST		YMFDLLLETR
KPDQVFQSYK		PGEVMVKVHV		VDLKAESVAA		PITVRAYLNQ		TVTEFKQLIS
KAIHLPAETM		RIVLERCYND		LRLLSVSSKT		LKAEGFFRSN		KVFVESSETL
DYQMAFADSH		LWKLLDRHAN		TIRLFVLLPE		QSPVSYSKRT		AYQKAGGDSG
NVDDDCERVK		GPVGSLKSVE		AILEESTEKL		KSLSLQQQQD		GDNGDSSKST
ETSDFENIES		PLNERDSSAS		VDNRELEQHI		QTSDPENFQS		EERSDSDVNN
DRSTSSVDSD		ILSSSHSSDT		LCNADNAQIP		LANGLDSHSI		TSSRRTKANE
GKKETWDTAE		EDSGTDSEYD		ESGKSRGEMQ		YMYFKAEPYA		ADEGSGEGHK
WLMVHVDKRI		TLAAFKQHLE		PFVGVLSSHF		KVFRVYASNQ		EFESVRLNET
LSSFSDDNKI		TIRLGRALKK		GEYRVKVYQL		LVNEQEPCKF		LLDAVFAKGM
TVRQSKEELI		PQLREQCGLE		LSIDRFRLRK		KTWKNPGTVF		LDYHIYEEDI
NISSNWEVFL		EVLDGVEKMK		SMSQLAVLSR		RWKPSEMKLD		PFQEVVLESS
SVDELREKLS		EISGIPLDDI		EFAKGRGTFP		CDISVLDIHQ		DLDWNPKVST
LNVWPLYICD		DGAVIFYRDK		TEELMELTDE		QRNELMKKES		SRLQKTGHRV
TYSPRKEKAL		KIYLDGAPNK		DLTQD

Reference

1. GRCh38: Ensembl release 89: ENSG00000170242 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059263 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
6. "Entrez Gene: USP47 ubiquitin specific peptidase 47".
7. "UniProt, Q96K76". Pristupljeno 29. 8. 2021.

Dopunska literatura

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
• Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
• Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

Vanjski linkovi