UNC5CL

UNC5CL
Identifikatori
Aliasi	UNC5CL
Vanjski ID-jevi	OMIM: 617464 MGI: 1923839 HomoloGene: 18319 GeneCards: UNC5CL
Lokacija gena (čovjek) Hrom. Hromosom 6 (čovjek)[1] Bend 6p21.1 Početak 41,026,895 bp[1] Kraj 41,039,221 bp[1]
Lokacija gena (miš) Hrom. Hromosom 17 (miš)[2] Bend 17|17 C Početak 48,761,929 bp[2] Kraj 48,846,742 bp[2]
Ontologija gena Molekularna funkcija • GO:0070122 peptidase activity • netrin receptor activity Ćelijska komponenta • citoplazma • integral component of membrane • membrana Biološki proces • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of JNK cascade • GO:0072468 Transdukcija signala • Proteoliza • netrin-activated signaling pathway Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	222643	76589
Ensembl	ENSG00000124602	ENSMUSG00000043592
UniProt	Q8IV45	Q6R653
RefSeq (mRNK)	NM_173561	NM_152823
RefSeq (bjelančevina)	NP_775832	n/a
Lokacija (UCSC)	Chr 6: 41.03 – 41.04 Mb	Chr 17: 48.76 – 48.85 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Homolog A proteina Unc-93 (C. elegans) jest protein koji je kod ljudi kodiran genom UNC93A.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 457 aminokiselina, а molekulska težina 50.270 Da.^[6]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MDRSLRNVLV		VSFGFLLLFT		AYGGLQSLQS		SLYSEEGLGV		TALSTLYGGM
LLSSMFLPPL		LIERLGCKGT		IILSMCGYVA		FSVGNFFASW		YTLIPTSILL
GLGAAPLWSA		QCTYLTITGN		THAEKAGKRG		KDMVNQYFGI		FFLIFQSSGV
WGNLISSLVF		GQTPSQETLP		EEQLTSCGAS		DCLMATTTTN		STQRPSQQLV
YTLLGIYTGS		GVLAVLMIAA		FLQPIRDVQR		ESEGEKKSVP		FWSTLLSTFK
LYRDKRLCLL		ILLPLYSGLQ		QGFLSSEYTR		SYVTCTLGIQ		FVGYVMICFS
ATDALCSVLY		GKVSQYTGRA		VLYVLGAVTH		VSCMIALLLW		RPRADHLAVF
FVFSGLWGVA		DAVWQTQNNA		LYGVLFEKSK		EAAFANYRLW		EALGFVIAFG
YSMFLCVHVK		LYILLGVLSL		TMVAYGLVEC		VESKNPIRPH		APGQVNQAED
EEIQTKM

Funkcija

Unc93A je natporodica (MFS) i navodno rastvornih nosača kod ljudi.^[7][8] Pripada atipskim SLC-ovima koji su nedavno referirani.^[7] Stoga se pretpostavlja  da je UNC93A transportni protein.

UNC93A je blisko  povezan sa proteinima UNC93B1 i MFSD11.^[9][10]

Na UNC93A utiče nedostatak aminokiselina u kulturama ćelija korteksa ^[8][9] i izgladnjivanje u uvjetima  in vivo  .^[9]

Eksprimira se u neuronima, sa bojenjem blizu plazmamembrana.^[9]

Reference

1. GRCh38: Ensembl release 89: ENSG00000124602 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043592 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Unc-93 homolog A (C. elegans)".
6. "UniProt, Q86WB7" (jezik: engleski). Pristupljeno 5. 10. 2021.
7. Perland E, Fredriksson R (mart 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
8. Perland E, Bagchi S, Klaesson A, Fredriksson R (septembar 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
9. Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience (jezik: English). 10: 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.
10. Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.

Dopunska literatura

• Liu Y, Dodds P, Emilion G, Mungall AJ, Dunham I, Beck S, Wells RS, Charnock FM, Ganesan TS (oktobar 2002). "The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer". BMC Genetics. 3: 20. doi:10.1186/1471-2156-3-20. PMC 134458. PMID 12381271.