TMPRSS11D
Serin 11D transmembranska proteaza , enzim koji je kod ljudi kodiran genom TMPRSS11D sa hromosoma 4 .[ 5] [ 6] [ 7]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 418 aminokiselina , а molekulska težina 46.263 Da .[ 8]
10 20 30 40 50 MYRPARVTST SRFLNPYVVC FIVVAGVVIL AVTIALLVYF LAFDQKSYFY RSSFQLLNVE YNSQLNSPAT QEYRTLSGRI ESLITKTFKE SNLRNQFIRA HVAKLRQDGS GVRADVVMKF QFTRNNNGAS MKSRIESVLR QMLNNSGNLE INPSTEITSL TDQAAANWLI NECGAGPDLI TLSEQRILGG TEAEEGSWPW QVSLRLNNAH HCGGSLINNM WILTAAHCFR SNSNPRDWIA TSGISTTFPK LRMRVRNILI HNNYKSATHE NDIALVRLEN SVTFTKDIHS VCLPAATQNI PPGSTAYVTG WGAQEYAGHT VPELRQGQVR IISNDVCNAP HSYNGAILSG MLCAGVPQGG VDACQGDSGG PLVQEDSRRL WFIVGIVSWG DQCGLPDKPG VYTRVTAYLD WIRQQTGI
Funkcija
Ovaj gen kodira tripsinu sličnu serin -proteazu koja se oslobađa iz submukozel serozne žlijezde na sluzničnu membranu. To je integralni membranski protein tipa II i ima 29-38% identiteta u sekvenci katalitske regije sa ljudskim hepsinom , enteropeptidazom , akrozinom , i mastocitnom triptazom . Nekatalitska regija ima malo sličnosti s drugim poznatim proteinima. Ovaj protein može imati određenu biološku ulogu u odbrambenom sistemu domaćina na sluzokožama , nezavisno ili u saradnji sa drugim supstancama u sluzokoži disajnih puteva ili bronhijskim sekretima.[ 7]
Reference
^ a b c GRCh38: Ensembl release 89: ENSG00000153802 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061259 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Yamaoka K, Masuda K, Ogawa H, Takagi K, Umemoto N, Yasuoka S (Jun 1998). "Cloning and characterization of the cDNA for human airway trypsin-like protease" . J Biol Chem . 273 (19): 11895–901. doi :10.1074/jbc.273.19.11895 PMID 9565616 . ^ Yasuoka S, Ohnishi T, Kawano S, Tsuchihashi S, Ogawara M, Masuda K, Yamaoka K, Takahashi M, Sano T (Apr 1997). "Purification, characterization, and localization of a novel trypsin-like protease found in the human airway". Am J Respir Cell Mol Biol . 16 (3): 300–8. doi :10.1165/ajrcmb.16.3.9070615 . PMID 9070615 . ^ a b "Entrez Gene: TMPRSS11D transmembrane protease, serine 11D" .^ "UniProt, O60235" (jezik: engleski). Pristupljeno 29. 10. 2021 .
Dopunska literatura
Takahashi M, Sano T, Yamaoka K, et al. (2001). "Localization of human airway trypsin-like protease in the airway: an immunohistochemical study". Histochem. Cell Biol . 115 (3): 181–7. doi :10.1007/s004180000243 . PMID 11326745 . S2CID 25025224 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Miki M, Nakamura Y, Takahashi A, et al. (2003). "Effect of human airway trypsin-like protease on intracellular free Ca2+ concentration in human bronchial epithelial cells". J. Med. Invest . 50 (1–2): 95–107. PMID 12630574 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Iwakiri K, Ghazizadeh M, Jin E, et al. (2004). "Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris" . J. Invest. Dermatol . 122 (4): 937–44. doi :10.1111/j.0022-202X.2004.22415.x PMID 15102084 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Matsushima R, Takahashi A, Nakaya Y, et al. (2006). "Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway". Am. J. Physiol. Lung Cell Mol. Physiol . 290 (2): L385–95. doi :10.1152/ajplung.00098.2005 . PMID 16199437 . Chokki M, Eguchi H, Hamamura I, et al. (2006). "Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells" . FEBS J . 272 (24): 6387–99. doi :10.1111/j.1742-4658.2005.05035.x PMID 16336275 . S2CID 34294232 . Böttcher E, Matrosovich T, Beyerle M, et al. (2006). "Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium" . J. Virol . 80 (19): 9896–8. doi :10.1128/JVI.01118-06 . PMC 1617224 PMID 16973594 .
Vanjski linkovi
