THAP7
THAP7 Identifikatori Aliasi THAP7 Vanjski ID-jevi OMIM : 609518 MGI : 1916259 HomoloGene : 12293 GeneCards : THAP7 Ontologija gena Molekularna funkcija • vezivanje sa DNK • C2H2 zinc finger domain binding • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje iona metala • protein N-terminus binding • nucleic acid binding • vezivanje identičnih proteina • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • nuclear speck • hromosom • jedro • Jedarna membrana • intracellular membrane-bounded organelle Biološki proces • GO:0045996 negative regulation of transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi Vrste Čovjek Miš Entrez Ensembl UniProt RefSeq (mRNK) RefSeq (bjelančevina) Lokacija (UCSC) Chr 22: 21 – 21 Mb Chr 16: 17.35 – 17.35 Mb PubMed pretraga[ 3] [ 4] Wikipodaci
Protein 7 sa THAP domenom jest protein koji je kod ljudi kodiran genom THAP7 sa hromosoma 22 .[ 5] [ 6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 309 aminokiselina , a molekulska težina 34.414 Da .[ 6]
10 20 30 40 50 MPRHCSAAGC CTRDTRETRN RGISFHRLPK KDNPRRGLWL ANCQRLDPSG QGLWDPASEY IYFCSKHFEE DCFELVGISG YHRLKEGAVP TIFESFSKLR RTTKTKGHSY PPGPAEVSRL RRCRKRCSEG RGPTTPFSPP PPADVTCFPV EEASAPATLP ASPAGRLEPG LSSPFSDLLG PLGAQADEAG CSAQPSPERQ PSPLEPRPVS PSAYMLRLPP PAGAYIQNEH SYQVGSALLW KRRAEAALDA LDKAQRQLQA CKRREQRLRL RLTKLQQERA REKRAQADAR QTLKEHVQDF AMQLSSSMA
Reference
^ a b c GRCh38: Ensembl release 89: ENSG00000184436 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022760 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Roussigne M, Kossida S, Lavigne AC, Clouaire T, Ecochard V, Glories A, Amalric F, Girard JP (Feb 2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci . 28 (2): 66–9. doi :10.1016/S0968-0004(02)00013-0 . PMID 12575992 . ^ a b "Entrez Gene: THAP7 THAP domain containing 7" .
Dopunska literatura
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome . 16 (12): 942–54. doi :10.1007/s00335-005-0075-2 . PMID 16341674 . S2CID 69278 . Macfarlan T, Parker JB, Nagata K, Chakravarti D (2006). "Thanatos-associated protein 7 associates with template activating factor-Ibeta and inhibits histone acetylation to repress transcription" . Mol. Endocrinol . 20 (2): 335–47. doi :10.1210/me.2005-0248 PMID 16195249 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Macfarlan T, Kutney S, Altman B, et al. (2005). "Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor" . J. Biol. Chem . 280 (8): 7346–58. doi :10.1074/jbc.M411675200 PMID 15561719 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome" . Genome Biol . 5 (10): R84. doi :10.1186/gb-2004-5-10-r84 . PMC 545604 PMID 15461802 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 .
