RCP9

RCP9
Identifikatori
Aliasi	CRCP
Vanjski ID-jevi	OMIM: 606121 MGI: 1100818 HomoloGene: 40587 GeneCards: CRCP
Lokacija gena (čovjek) Hrom. Hromosom 7 (čovjek)[1] Bend 7q11.21 Početak 66,114,604 bp[1] Kraj 66,154,568 bp[1]
Lokacija gena (miš) Hrom. Hromosom 5 (miš)[2] Bend 5|5 G1.3 Početak 130,058,131 bp[2] Kraj 130,089,630 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • nucleotide binding • RNA polymerase III activity • DNA-directed 5'-3' RNA polymerase activity • GO:0001948, GO:0016582 vezivanje za proteine • catalytic activity • calcitonin gene-related peptide receptor activity Ćelijska komponenta • citosol • membrana • ćelijska membrana • nukleoplazma • Akrozom • DNA polymerase III complex • jedro • RNA polymerase III complex • nuclear DNA-directed RNA polymerase complex • RNA polymerase complex Biološki proces • immune system process • cell metabolism • defense response to virus • neuropeptide signaling pathway • transcription by RNA polymerase III • Urođeni imunski sistem • DNA-templated transcription, initiation • transcription initiation from RNA polymerase III promoter • positive regulation of type I interferon production Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	27297	12909
Ensembl	ENSG00000241258	ENSMUSG00000025532
UniProt	O75575	O35427
RefSeq (mRNK)	NM_001040647 NM_001040648 NM_001142414 NM_014478	NM_007761
RefSeq (bjelančevina)	NP_001035737 NP_001035738 NP_001135886 NP_055293	NP_031787
Lokacija (UCSC)	Chr 7: 66.11 – 66.15 Mb	Chr 5: 130.06 – 130.09 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Podjedinica RPC9 DNK-usmjerene RNK polimeraze III je enzim koji je kod ljudi kodiran genom CRCP.^[5][6][7][8]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 148 aminokiselina, а molekulska težina 16.871 Da.^[9]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MEVKDANSAL		LSNYEVFQLL		TDLKEQRKES		GKNKHSSGQQ		NLNTITYETL
KYISKTPCRH		QSPEIVREFL		TALKSHKLTK		AEKLQLLNHR		PVTAVEIQLM
VEESEERLTE		EQIEALLHTV		TSILPAEPEA		EQKKNTNSNV		AMDEEDPA

Funkcija

Ovaj gen kodira membranski protein koji funkcionira kao dio receptorskog kompleksa za mali neuropeptid koji povećava unutarćelijske nivoe cAMP-a. Opisane su alternativno prerađene varijante transkripcije, koje kodiraju različite izoforme.^[8]

Reference

1. GRCh38: Ensembl release 89: ENSG00000241258 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025532 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Luebke AE, Dahl GP, Roos BA, Dickerson IM (Jun 1996). "Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay". Proc Natl Acad Sci U S A. 93 (8): 3455–60. doi:10.1073/pnas.93.8.3455. PMC 39630. PMID 8622957.
6. Balkan W, Oates EL, Howard GA, Roos BA (Mar 1999). "Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein". Endocrinology. 140 (3): 1459–69. doi:10.1210/en.140.3.1459. PMID 10067875.
7. Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C (Dec 2002). "An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP". Mol Cell Biol. 23 (1): 195–205. doi:10.1128/MCB.23.1.195-205.2003. PMC 140662. PMID 12482973.
8. "Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein".
9. "UniProt, O75575" (jezik: engleski). Pristupljeno 28. 9. 2021.

Dopunska literatura

• Yallampalli C, Chauhan M, Thota CS, et al. (2003). "Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity". Trends Endocrinol. Metab. 13 (6): 263–9. doi:10.1016/s1043-2760(02)00563-5. PMID 12128288. S2CID 28476322.
• Evans BN, Rosenblatt MI, Mnayer LO, et al. (2000). "CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors". J. Biol. Chem. 275 (40): 31438–43. doi:10.1074/jbc.M005604200. PMID 10903324.
• Prado MA, Evans-Bain B, Oliver KR, Dickerson IM (2002). "The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction". Peptides. 22 (11): 1773–81. doi:10.1016/S0196-9781(01)00517-4. PMID 11754963. S2CID 37139980.
• Moreno MJ, Terrón JA, Stanimirovic DB, et al. (2002). "Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture". Neuropharmacology. 42 (2): 270–80. doi:10.1016/S0028-3908(01)00176-9. PMID 11804624. S2CID 45479910.
• Harzenetter MD, Keller U, Beer S, et al. (2002). "Regulation and function of the CGRP receptor complex in human granulopoiesis". Exp. Hematol. 30 (4): 306–12. doi:10.1016/S0301-472X(02)00772-5. PMID 11937264.
• Hu P, Wu S, Sun Y, et al. (2002). "Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits" (PDF). Mol. Cell. Biol. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170. Arhivirano s originala (PDF), 22. 9. 2017. Pristupljeno 28. 9. 2021.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hasbak P, Saetrum Opgaard O, Eskesen K, et al. (2003). "Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist". J. Pharmacol. Exp. Ther. 304 (1): 326–33. doi:10.1124/jpet.102.037754. PMID 12490608. S2CID 14045615.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Zuccarello D, Morini E, Douzgou S, et al. (2005). "Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism". J. Endocrinol. Invest. 27 (8): 760–4. doi:10.1007/bf03347519. PMID 15636430. S2CID 19253890.
• Krämer HH, Schmidt K, Leis S, et al. (2006). "Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin". Peptides. 27 (4): 917–20. doi:10.1016/j.peptides.2005.08.007. PMID 16406141. S2CID 24455456.

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