PSRC1

PSRC1
Identifikatori
Aliasi	PSRC1
Vanjski ID-jevi	OMIM: 613126 MGI: 1913099 HomoloGene: 49603 GeneCards: PSRC1
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1p13.3 Početak 109,279,556 bp[1] Kraj 109,283,186 bp[1]
Lokacija gena (miš) Hrom. Hromosom 3 (miš)[2] Bend 3|3 F3 Početak 108,291,155 bp[2] Kraj 108,295,547 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • microtubule binding Ćelijska komponenta • spindle microtubule • citoskelet • Diobeno vreteno • citosol • microtubule cytoskeleton • spindle pole • midbody • citoplazma • nukleoplazma Biološki proces • mitotic metaphase plate congression • negative regulation of cell growth • microtubule bundle formation • regulation of mitotic spindle organization • Ćelijska dioba • ćelijski ciklus • GO:0006928 cellular process or phenomenon • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of microtubule polymerization • positive regulation of cyclin-dependent protein serine/threonine kinase activity Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	84722	56742
Ensembl	ENSG00000134222	ENSMUSG00000068744
UniProt	Q6PGN9 Q5T2Z0	Q9D0P7
RefSeq (mRNK)	NM_001005290 NM_001032290 NM_001032291 NM_032636 NM_001350237 NM_001350238 NM_001350239 NM_001350240 NM_001350241 NM_001350242 NM_001363309 NM_001394002 NM_001394003 NM_001394004 NM_001394005	NM_001190161 NM_019976
RefSeq (bjelančevina)	NP_001005290 NP_001027462 NP_116025 NP_001337166 NP_001337167 NP_001337168 NP_001337169 NP_001337170 NP_001337171 NP_001350238	NP_001177090 NP_064360
Lokacija (UCSC)	Chr 1: 109.28 – 109.28 Mb	Chr 3: 108.29 – 108.3 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Prolinom/serinom-bogati upredenozavojnički protein 1 jest protein koji je kod ljudi kodiran genom PSRC1 sa hromosoma 1.^[5][6][7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 363 aminokiseline, a molekulska težina 38.796 Da.^[8]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MEDLEEDVRF		IVDETLDFGG		LSPSDSREEE		DITVLVTPEK		PLRRGLSHRS
DPNAVAPAPQ		GVRLSLGPLS		PEKLEEILDE		ANRLAAQLEQ		CALQDRESAG
EGLGPRRVKP		SPRRETFVLK		DSPVRDLLPT		VNSLTRSTPS		PSSLTPRLRS
NDRKGSVRAL		RATSGKRPSN		MKRESPTCNL		FPASKSPASS		PLTRSTPPVR
GRAGPSGRAA		ASEETRAAKL		RVSGSGEFVG		LTLKFLHPSP		PGPPTPIRSV
LAPQPSTSNS		QRLPRPQGAA		AKSSSQLPIP		SAIPRPASRM		PLTSRSVPPG
RGALPPDSLS		TRKGLPRPST		AGHRVRESGH		KVPVSQRLNL		PVMGATRSNL
QPPRKVAVPG		PTR

Funkcija

Ovaj gen kodira protein bogat prolinom. Studije srodnog mišjeg gena sugeriraju da je ovaj gen reguliran putem p53 i da može učestvovati u supresiji rasta posredovanoj preko p53. Opisane su alternativno prerađene varijante transkripta koje kodiraju različite izoforme.^[7]

Reference

1. GRCh38: Ensembl release 89: ENSG00000134222 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000068744 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lo PK, Wang FF (Nov 2002). "Cloning and characterization of human and mouse DDA3 genes". Biochim Biophys Acta. 1579 (2–3): 214–8. doi:10.1016/s0167-4781(02)00512-2. PMID 12427559.
6. Lo PK, Chen JY, Lo WC, Chen BF, Hsin JP, Tang PP, Wang FF (Feb 2000). "Identification of a novel mouse p53 target gene DDA3". Oncogene. 18 (54): 7765–74. doi:10.1038/sj.onc.1203167. PMID 10618717.
7. "Entrez Gene: PSRC1 proline/serine-rich coiled-coil 1".
8. "UniProt, Q6PGN9" (jezik: eng.). Pristupljeno 4. 12. 2021.

Dopunska literatura

• Kathiresan S, Melander O, Guiducci C, et al. (2008). "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans". Nat. Genet. 40 (2): 189–97. doi:10.1038/ng.75. PMC 2682493. PMID 18193044.
• Wallace C, Newhouse SJ, Braund P, et al. (2008). "Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia". Am. J. Hum. Genet. 82 (1): 139–49. doi:10.1016/j.ajhg.2007.11.001. PMC 2253977. PMID 18179892.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.