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GTPBP4
Identifikatori
Aliasi	GTPBP4
Vanjski ID-jevi	MGI: 1916487 HomoloGene: 7100 GeneCards: GTPBP4
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	1,019,932 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	9,046,119 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • GTP binding; • GO:0001948, GO:0016582 vezivanje za proteine; • GO:0006184 GTPase activity; • vezivanje sa RNK;
Ćelijska komponenta	• citoplazma; • Golđijev aparat; • Jedarna membrana; • membrana; • Jedarce; • perinuklearno područje citoplazme; • jedro; • citosol;
Biološki proces	• regulation of cyclin-dependent protein serine/threonine kinase activity; • ribosome biogenesis; • negative regulation of cell-cell adhesion; • protein stabilization; • negative regulation of DNA replication; • negative regulation of protein ubiquitination; • negative regulation of cell migration; • osteoblast differentiation; • negative regulation of collagen binding; • negative regulation of cell population proliferation; • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);
	Izvori:Amigo / QuickGO
Ortolozi
	23560
	69237
	ENSG00000107937
	ENSMUSG00000021149
	Q9BZE4
	Q99ME9
	NM_012341
	NM_027000
	NP_036473
	NP_081276
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Jedarcetov GTP-vezujući protein 1 je protein koji je kod ljudi kodiran genom GTPBP4.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 634 aminokiseline, а molekulska težina 73.964 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAHYNFKKIT	VVPSAKDFID	LTLSKTQRKT	PTVIHKHYQI	HRIRHFYMRK
VKFTQQNYHD	RLSQILTDFP	KLDDIHPFYA	DLMNILYDKD	HYKLALGQIN
IAKNLVDNVA	KDYVRLMKYG	DSLYRCKQLK	RAALGRMCTV	IKRQKQSLEY
LEQVRQHLSR	LPTIDPNTRT	LLLCGYPNVG	KSSFINKVTR	ADVDVQPYAF
TTKSLFVGHM	DYKYLRWQVV	DTPGILDHPL	EDRNTIEMQA	ITALAHLRAA
VLYVMDLSEQ	CGHGLREQLE	LFQNIRPLFI	NKPLIVVANK	CDVKRIAELS
EDDQKIFTDL	QSEGFPVIET	STLTEEGVIK	VKTEACDRLL	AHRVETKMKG
NKVNEVLNRL	HLAIPTRRDD	KERPPFIPEG	VVARRKRMET	EESRKKRERD
LELEMGDDYI	LDLQKYWDLM	NLSEKHDKIP	EIWEGHNIAD	YIDPAIMKKL
EELEKEEELR	TAAGEYDSVS	ESEDEEMLEI	RQLAKQIREK	KKLKILESKE
KNTQGPRMPR	TAKKVQRTVL	EKEMRSLGVD	MDDKDDAHYA	VQARRSRSIT
RKRKREDSAP	PSSVARSGSC	SRTPRDVSGL	RDVKMVKKAK	TMMKNAQKKM
NRLGKKGEAD	RHVFDMKPKH	LLSGKRKAGK	KDRR

Funkcija

GTPaze funkcioniraju kao molekulni prekidači koji se mogu prebacivati između dva stanja: aktivno, kada je GTP vezan, i neaktivno, kada je vezan BDP. 'Aktivno' obično znači da molekula djeluje kao signal za pokretanje drugih događaja u ćeliji. Kad se vanćelijski ligand veže za G-protein spregnuti receptor, receptor mijenja svoju konformaciju i uključuje trimerne G-proteine, koji se povezuju s njim, izazivajući ih da izbace svoj BDP i zamijene ga GTP-om. Prekidač se isključuje kada G-protein hidrolizira svoj vezani GTP, pretvarajući ga nazad u BDP. No, prije nego što se to dogodi, aktivni protein ima priliku difundirati dalje od receptora i prenositi svoju poruku na duži period do svog nizvodnog cilja.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107937 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021149 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Laping NJ, Olson BA, Zhu Y (Apr 2001). "Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease". J Am Soc Nephrol. 12 (5): 883–90. doi:10.1681/ASN.V125883. PMID 11316846.
^ ^a ^b "Entrez Gene: GTPBP4 GTP binding protein 4".
^ "UniProt, Q9BZE4". Pristupljeno 3. 9. 2021.

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Lee H, Kim D, Dan HC, et al. (2007). "Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein". Mol. Cell. Biol. 27 (6): 2103–19. doi:10.1128/MCB.00572-06. PMC 1820506. PMID 17210637.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107937 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021149 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11316846-5] Laping NJ, Olson BA, Zhu Y (Apr 2001). "Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease". J Am Soc Nephrol. 12 (5): 883–90. doi:10.1681/ASN.V125883. PMID 11316846.

[entrez-6] "Entrez Gene: GTPBP4 GTP binding protein 4".

[UniProt-7] "UniProt, Q9BZE4". Pristupljeno 3. 9. 2021.

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