GNL2

GNL2
Identifikatori
Aliasi	GNL2
Vanjski ID-jevi	OMIM: 609365 MGI: 2385207 HomoloGene: 6858 GeneCards: GNL2
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1p34.3 Početak 37,566,816 bp[1] Kraj 37,595,937 bp[1]
Lokacija gena (miš) Hrom. Hromosom 4 (miš)[2] Bend 4|4 D2.2 Početak 124,910,378 bp[2] Kraj 124,949,173 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • nucleotide binding • GTP binding • vezivanje sa RNK • GO:0006184 GTPase activity Ćelijska komponenta • membrana • jedro • Jedarce • integral component of membrane Biološki proces • ribosome biogenesis • GO:0022610 biološki proces Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	29889	230737
Ensembl	ENSG00000134697	ENSMUSG00000028869
UniProt	Q13823	Q99LH1
RefSeq (mRNK)	NM_013285 NM_001323623 NM_001323624	NM_145552
RefSeq (bjelančevina)	NP_001310552 NP_001310553 NP_037417	NP_663527
Lokacija (UCSC)	Chr 1: 37.57 – 37.6 Mb	Chr 4: 124.91 – 124.95 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Jedarcetov GTP-vezujući protein 2 jest protein koji je kod ljudi kodiran genom GNL2 sa hromosoma 1.^[5][6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 731 aminokiselina, a molekulska težina 83.655 Da.^[7]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MVKPKYKGRS		TINPSKASTN		PDRVQGAGGQ		NMRDRATIRR		LNMYRQKERR
NSRGKIIKPL		QYQSTVASGT		VARVEPNIKW		FGNTRVIKQS		SLQKFQEEMD
TVMKDPYKVV		MKQSKLPMSL		LHDRIRPHNL		KVHILDTESF		ETTFGPKSQR
KRPNLFASDM		QSLIENAEMS		TESYDQGKDR		DLVTEDTGVR		NEAQEEIYKK
GQSKRIWGEL		YKVIDSSDVV		VQVLDARDPM		GTRSPHIETY		LKKEKPWKHL
IFVLNKCDLV		PTWATKRWVA		VLSQDYPTLA		FHASLTNPFG		KGAFIQLLRQ
FGKLHTDKKQ		ISVGFIGYPN		VGKSSVINTL		RSKKVCNVAP		IAGETKVWQY
ITLMRRIFLI		DCPGVVYPSE		DSETDIVLKG		VVQVEKIKSP		EDHIGAVLER
AKPEYISKTY		KIDSWENAED		FLEKLAFRTG		KLLKGGEPDL		QTVGKMVLND
WQRGRIPFFV		KPPNAEPLVA		PQLLPSSSLE		VVPEAAQNNP		GEEVTETAGE
GSESIIKEET		EENSHCDANT		EMQQILTRVR		QNFGKINVVP		QFSGDDLVPV
EVSDLEEELE		SFSDEEEEEQ		EQQRDDAEES		SSEPEEENVG		NDTKAVIKAL
DEKIAKYQKF		LDKAKAKKFS		AVRISKGLSE		KIFAKPEEQR		KTLEEDVDDR
APSKKGKKRK		AQREEEQEHS		NKAPRALTSK		ERRRAVRQQR		PKKVGVRYYE
THNVKNRNRN		KKKTNDSEGQ		KHKRKKFRQK		Q

Reference

1. GRCh38: Ensembl release 89: ENSG00000134697 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028869 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Racevskis J, Dill A, Stockert R, Fineberg SA (Mar 1997). "Cloning of a novel nucleolar guanosine 5'-triphosphate binding protein autoantigen from a breast tumor". Cell Growth Differ. 7 (2): 271–80. PMID 8822211.
6. "Entrez Gene: GNL2 guanine nucleotide binding protein-like 2 (nucleolar)".
7. "UniProt, Q13823" (jezik: eng.). Pristupljeno 28. 11. 2021.

Dopunska literatura

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.