FLOT2

FLOT2
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1WIN
Identifikatori
Aliasi	FLOT2
Vanjski ID-jevi	OMIM: 131560 MGI: 103309 HomoloGene: 3293 GeneCards: FLOT2
Lokacija gena (čovjek) Hrom. Hromosom 17 (čovjek)[1] Bend 17q11.2 Početak 28,879,335 bp[1] Kraj 28,897,733 bp[1]
Lokacija gena (miš) Hrom. Hromosom 11 (miš)[2] Bend 11 B5|11 46.74 cM Početak 77,928,757 bp[2] Kraj 77,951,260 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • protease binding • GO:0001948, GO:0016582 vezivanje za proteine • protein heterodimerization activity • ionotropic glutamate receptor binding Ćelijska komponenta • Vezikula • endozom • membrana • cell-cell contact zone • focal adhesion • endocytic vesicle • acrosomal membrane • flotillin complex • uropod • basolateral plasma membrane • apical plasma membrane • cortical actin cytoskeleton • perinuklearno područje citoplazme • Kaveole • Lipidni splav • Egzosom • GO:0016023 citoplazmatska vezikula • lamellipodium • ćelijska membrana • dendrite cytoplasm • sinapsa • glutamatergic synapse • anchored component of presynaptic active zone membrane Biološki proces • positive regulation of establishment of T cell polarity • regulation of toll-like receptor 3 signaling pathway • regulation of heterotypic cell-cell adhesion • protein stabilization • negative regulation of amyloid precursor protein catabolic process • negative regulation of gene expression • protein localization to plasma membrane raft • Ćelijska adhezija • membrane raft assembly • regulation of myoblast differentiation • epidermis development • protein localization to plasma membrane • anterograde dendritic transport • regulation of postsynaptic membrane neurotransmitter receptor levels • positive regulation of NF-kappaB transcription factor activity Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	2319	14252
Ensembl	ENSG00000132589	ENSMUSG00000061981
UniProt	Q14254	Q60634
RefSeq (mRNK)	NM_004475 NM_001330170	NM_001040403 NM_001284227 NM_001284228 NM_008028 NM_001362625 NM_001362626 NM_001362627
RefSeq (bjelančevina)	NP_001317099 NP_004466	NP_001035493 NP_001271156 NP_001271157 NP_032054 NP_001349554 NP_001349555 NP_001349556
Lokacija (UCSC)	Chr 17: 28.88 – 28.9 Mb	Chr 11: 77.93 – 77.95 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Flotilin-2 je protein koji je kod ljudi kodiran genom FLOT2.^[5][6]

Flotilin 2 (flot-2) je visoko konzervirani protein izoliran iz domena kaveol/ lipidnog splava koji vežu receptore faktora rasta na puteve signalne transdukcije. Flot-2 se veže za PAR-1, poznati uzvodni posrednik glavnih puteva transdukcije signala uključenih u rast ćelija i metastaze, a može uticati na progresiju tumora.^[7]

Kaveole su mali domeni na unutrašnjosti ćelijske membrane, uključene u promet vezikula i transdukciju signala. Ovaj gen kodira integrirani membranski protein povezan s kaveolama, za koji se smatra da djeluje u neuronskoj signalizaciji.^[6]

Dužina polipeptidnog lanca je 428 aminokiselina, a molekulska težina 47.064 Da.^[8].

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MGNCHTVGPN		EALVVSGGCC		GSDYKQYVFG		GWAWAWWCIS		DTQRISLEIM
TLQPRCEDVE		TAEGVALTVT		GVAQVKIMTE		KELLAVACEQ		FLGKNVQDIK
NVVLQTLEGH		LRSILGTLTV		EQIYQDRDQF		AKLVREVAAP		DVGRMGIEIL
SFTIKDVYDK		VDYLSSLGKT		QTAVVQRDAD		IGVAEAERDA		GIREAECKKE
MLDVKFMADT		KIADSKRAFE		LQKSAFSEEV		NIKTAEAQLA		YELQGAREQQ
KIRQEEIEIE		VVQRKKQIAV		EAQEILRTDK		ELIATVRRPA		EAEAHRIQQI
AEGEKVKQVL		LAQAEAEKIR		KIGEAEAAVI		EAMGKAEAER		MKLKAEAYQK
YGDAAKMALV		LEALPQIAAK		IAAPLTKVDE		IVVLSGDNSK		VTSEVNRLLA
ELPASVHALT		GVDLSKIPLI		KKATGVQV

Reference

1. GRCh38: Ensembl release 89: ENSG00000132589 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061981 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schroeder WT, Siciliano MJ, Stewart-Galetka SL, Duvic M (Feb 1992). "The human gene for an epidermal surface antigen (M17S1) is located at 17q11-12". Genomics. 11 (2): 481–2. doi:10.1016/0888-7543(91)90166-C. PMID 1769667.
6. "Entrez Gene: FLOT2 flotillin 2".
7. Hazarika P, McCarty MF, Prieto VG, George S, Babu D, Koul D, Bar-Eli M, Duvic M (Oct 2004). "Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1". Cancer Res. 64 (20): 7361–9. doi:10.1158/0008-5472.CAN-04-0823. PMID 15492257.
8. "UniProt, Q14254". Pristupljeno 21. 6. 2021.

Dopunska literatura

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• Hazarika P, McCarty MF, Prieto VG, et al. (2004). "Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1". Cancer Res. 64 (20): 7361–9. doi:10.1158/0008-5472.CAN-04-0823. PMID 15492257.
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