FBXO2

FBXO2
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1UMH, 1UMI, 2E31, 2E32, 2E33, 2RJ2
Identifikatori
Aliasi	FBXO2
Vanjski ID-jevi	OMIM: 607112 MGI: 2446216 HomoloGene: 8132 GeneCards: FBXO2
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1p36.22 Početak 11,637,018 bp[1] Kraj 11,655,785 bp[1]
Lokacija gena (miš) Hrom. Hromosom 4 (miš)[2] Bend 4 E2|4 78.68 cM Početak 148,245,078 bp[2] Kraj 148,250,881 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • amyloid-beta binding • carbohydrate binding • GO:0050372 aktivnost sa transferazom ubikvitina • GO:0001948, GO:0016582 vezivanje za proteine • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity Ćelijska komponenta • organelle membrane • membrana • SCF ubiquitin ligase complex • intracellular membrane-bounded organelle • dendritična kičma • Endoplazmatski retikulum • citosol • citoplazma Biološki proces • ubiquitin-dependent protein catabolic process • regulation of protein ubiquitination • Proteoliza • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • protein ubiquitination • ubiquitin-dependent ERAD pathway • glycoprotein catabolic process • negative regulation of cell population proliferation • protein polyubiquitination • Posttranslacione modifikacije Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	26232	230904
Ensembl	ENSG00000116661	ENSMUSG00000041556
UniProt	Q9UK22	Q80UW2
RefSeq (mRNK)	NM_012168	NM_176848
RefSeq (bjelančevina)	NP_036300	NP_789818
Lokacija (UCSC)	Chr 1: 11.64 – 11.66 Mb	Chr 4: 148.25 – 148.25 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Jedini F-kutijski protein 2 jest protein koji je kod ljudi kodiran genom FBXO2 sa hromosoma 1.^[5][6][7]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 296 aminokiselina, a molekulska težina 33.328 Da.^[8]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MDGDGDPESV		GQPEEASPEE		QPEEASAEEE		RPEDQQEEEA		AAAAAYLDEL
PEPLLLRVLA		ALPAAELVQA		CRLVCLRWKE		LVDGAPLWLL		KCQQEGLVPE
GGVEEERDHW		QQFYFLSKRR		RNLLRNPCGE		EDLEGWCDVE		HGGDGWRVEE
LPGDSGVEFT		HDESVKKYFA		SSFEWCRKAQ		VIDLQAEGYW		EELLDTTQPA
IVVKDWYSGR		SDAGCLYELT		VKLLSEHENV		LAEFSSGQVA		VPQDSDGGGW
MEISHTFTDY		GPGVRFVRFE		HGGQDSVYWK		GWFGARVTNS		SVWVEP

Funkcija

Ovaj gen kodira člana porodice F-kutijskih proteina koji se odlikuje motivom od približno 40 aminokiselina, F-kutijom. Proteini F-kutije čine jednu od četiri podjedinice ubikvitinske proteinskog ligaznog kompleksa zvanog SCFs (SKP1-kulin-F-kutija), koji funkcioniše u fosforilaciono-zavisnoj ubikvitinaciji .

Proteini F-kutije podijeljeni su u tri klase: Fbws koji sadrže WD-40 domen, Fbls koji sadrže leucin bogata ponavljanja i Fbxs koji sadrže ili različite module interakcije protein-protein ili ne sadrže prepoznatljive motive. Protein kodiran ovim genom pripada klasi Fbxs. Ovaj protein je veoma sličan pacovskom proteinu NFB42 (neuralni F-kutijski sa 42 kDa) koji je obogaćen u nervnom sistemu i može imati ulogu u održavanju neurona u postmitotskom stanju.^[7]

Reference

1. GRCh38: Ensembl release 89: ENSG00000116661 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041556 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
6. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
7. "Entrez Gene: FBXO2 F-box protein 2".
8. "UniProt, Q9UK22" (jezik: eng.). Pristupljeno 26. 11. 2021.

Dopunska literatura

• Erhardt JA, Hynicka W, DiBenedetto A, et al. (1999). "A novel F box protein, NFB42, is highly enriched in neurons and induces growth arrest". J. Biol. Chem. 273 (52): 35222–7. doi:10.1074/jbc.273.52.35222. PMID 9857061.
• Yoshida Y, Chiba T, Tokunaga F, et al. (2002). "E3 ubiquitin ligase that recognizes sugar chains". Nature. 418 (6896): 438–42. Bibcode:2002Natur.418..438Y. doi:10.1038/nature00890. PMID 12140560. S2CID 4424996.
• Ilyin GP, Sérandour AL, Pigeon C, et al. (2003). "A new subfamily of structurally related human F-box proteins". Gene. 296 (1–2): 11–20. doi:10.1016/S0378-1119(02)00867-3. PMID 12383498.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Eom CY, Lehman IR (2003). "Replication-initiator protein (UL9) of the herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathway". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9803–7. Bibcode:2003PNAS..100.9803E. doi:10.1073/pnas.1733876100. PMC 187846. PMID 12904574.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

Vanjski linkovi