ECOP

ECOP
Identifikatori
Aliasi	VOPP1
Vanjski ID-jevi	OMIM: 611915 MGI: 2141658 HomoloGene: 12772 GeneCards: VOPP1
Lokacija gena (čovjek) Hrom. Hromosom 7 (čovjek)[1] Bend 7p11.2 Početak 55,436,056 bp[1] Kraj 55,572,988 bp[1]
Lokacija gena (miš) Hrom. Hromosom 6 (miš)[2] Bend 6|6 B3 Početak 57,704,792 bp[2] Kraj 57,802,144 bp[2]
Ontologija gena Molekularna funkcija • signal transducer activity Ćelijska komponenta • integral component of membrane • integral component of organelle membrane • endozom • cytoplasmic vesicle membrane • membrana • GO:0016023 citoplazmatska vezikula Biološki proces • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	81552	232023
Ensembl	ENSG00000154978	ENSMUSG00000037788
UniProt	Q96AW1	Q8R1C3
RefSeq (mRNK)	NM_001284282 NM_001284283 NM_001284284 NM_030796 NM_001321242 NM_001321243 NM_001321244 NM_001321246 NM_001321247 NM_001321248 NM_001321249 NM_001321250 NM_001321251	NM_146168
RefSeq (bjelančevina)	NP_001271211 NP_001271212 NP_001271213 NP_001308171 NP_001308172 NP_001308173 NP_001308175 NP_001308176 NP_001308177 NP_001308178 NP_001308179 NP_001308180 NP_110423	NP_666280
Lokacija (UCSC)	Chr 7: 55.44 – 55.57 Mb	Chr 6: 57.7 – 57.8 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

EGFR- koamplificirani i preeksprimirani protein, takođe poznat i kao COP, jest ljudski gen.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 172 aminokiseline, а molekulska težina 19.224 Da.^[6]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MRRQPAKVAA		LLLGLLLECT		EAKKHCWYFE		GLYPTYYICR		SYEDCCGSRC
CVRALSIQRL		WYFWFLLMMG		VLFCCGAGFF		IRRRMYPPPL		IEEPAFNVSY
TRQPPNPGPG		AQQPGPPYYT		DPGGPGMNPV		GNSMAMAFQV		PPNSPQGSVA
CPPPPAYCNT		PPPPYEQVVK		AK

Reference

1. GRCh38: Ensembl release 89: ENSG00000154978 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037788 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ECOP EGFR-coamplified and overexpressed protein".
6. "UniProt, Q96AW1" (jezik: engleski). Pristupljeno 24. 9. 2021.

Dopunska literatura

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Park S, James CD (2005). "ECop (EGFR-coamplified and overexpressed protein), a novel protein, regulates NF-kappaB transcriptional activity and associated apoptotic response in an IkappaBalpha-dependent manner". Oncogene. 24 (15): 2495–502. doi:10.1038/sj.onc.1208496. PMID 15735698.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Brem H, Stojadinovic O, Diegelmann RF, et al. (2007). "Molecular Markers in Patients with Chronic Wounds to Guide Surgical Debridement". Mol. Med. 13 (1–2): 30–9. doi:10.2119/2006-00054.Brem. PMC 1869625. PMID 17515955.