DHX57

DHX57
Identifikatori
Aliasi	DHX57
Vanjski ID-jevi	MGI: 2147067 HomoloGene: 56267 GeneCards: DHX57
Lokacija gena (čovjek) Hrom. Hromosom 2 (čovjek)[1] Bend 2p22.1 Početak 38,797,729 bp[1] Kraj 38,875,934 bp[1]
Lokacija gena (miš) Hrom. Hromosom 17 (miš)[2] Bend 17|17 E3 Početak 80,238,309 bp[2] Kraj 80,290,476 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • nucleotide binding • GO:0001948, GO:0016582 vezivanje za proteine • hydrolase activity • ATP binding • GO:0008026 helicase activity • vezivanje iona metala • nucleic acid binding • vezivanje sa RNK • GO:0034459 3'-5' RNA helicase activity Ćelijska komponenta • mitohondrija Biološki proces • GO:0033168, GO:0036404, GO:1902360 RNA processing Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	90957	106794
Ensembl	ENSG00000163214	ENSMUSG00000035051
UniProt	Q6P158 Q8N4U2	Q6P5D3
RefSeq (mRNK)	NM_198963 NM_001329963 NM_144995 NM_145646	NM_001163759 NM_198942
RefSeq (bjelančevina)	NP_001316892 NP_945314 NP_945314.1	NP_001157231 NP_945180
Lokacija (UCSC)	Chr 2: 38.8 – 38.88 Mb	Chr 17: 80.24 – 80.29 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Navodna ATP-ovisna RNK-helikaza DHX57 jest enzim koji je kod ljudi kodiran genom DHX57 sa hromosoma 2.^[5]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 1.386 aminokiselina, a molkekulska iežina 155.604 Da.^[6]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSSSVRRKGK		PGKGGGKGSS		RGGRGGRSHA		SKSHGSGGGG		GGGGGGGGGN
RKASSRIWDD		GDDFCIFSES		RRPSRPSNSN		ISKGESRPKW		KPKAKVPLQT
LHMTSENQEK		VKALLRDLQE		QDADAGSERG		LSGEEEDDEP		DCCNDERYWP
AGQEPSLVPD		LDPLEYAGLA		SVEPYVPEFT		VSPFAVQKLS		RYGFNTERCQ
AVLRMCDGDV		GASLEHLLTQ		CFSETFGERM		KISEAVNQIS		LDECMEQRQE
EAFALKSICG		EKFIERIQNR		VWTIGLELEY		LTSRFRKSKP		KESTKNVQEN
SLEICKFYLK		GNCKFGSKCR		FKHEVPPNQI		VGRIERSVDD		SHLNAIEDAS
FLYELEIRFS		KDHKYPYQAP		LVAFYSTNEN		LPLACRLHIS		EFLYDKALTF
AETSEPVVYS		LITLLEEESE		IVKLLTNTHH		KYSDPPVNFL		PVPSRTRINN
PACHKTVIPN		NSFVSNQIPE		VEKASESEES		DEDDGPAPVI		VENESYVNLK
KKISKRYDWQ		AKSVHAENGK		ICKQFRMKQA		SRQFQSILQE		RQSLPAWEER
ETILNLLRKH		QVVVISGMTG		CGKTTQIPQF		ILDDSLNGPP		EKVANIICTQ
PRRISAISVA		ERVAKERAER		VGLTVGYQIR		LESVKSSATR		LLYCTTGVLL
RRLEGDTALQ		GVSHIIVDEV		HERTEESDFL		LLVLKDIVSQ		RPGLQVILMS
ATLNAELFSD		YFNSCPVITI		PGRTFPVDQF		FLEDAIAVTR		YVLQDGSPYM
RSMKQISKEK		LKARRNRTAF		EEVEEDLRLS		LHLQDQDSVK		DAVPDQQLDF
KQLLARYKGV		SKSVIKTMSI		MDFEKVNLEL		IEALLEWIVD		GKHSYPPGAI
LVFLPGLAEI		KMLYEQLQSN		SLFNNRRSNR		CVIHPLHSSL		SSEEQQAVFV
KPPAGVTKII		ISTNIAETSI		TIDDVVYVID		SGKMKEKRYD		ASKGMESLED
TFVSQANALQ		RKGRAGRVAS		GVCFHLFTSH		HYNHQLLKQQ		LPEIQRVPLE
QLCLRIKILE		MFSAHNLQSV		FSRLIEPPHT		DSLRASKIRL		RDLGALTPDE
RLTPLGYHLA		SLPVDVRIGK		LMLFGSIFRC		LDPALTIAAS		LAFKSPFVSP
WDKKEEANQK		KLEFAFANSD		YLALLQAYKG		WQLSTKEGVR		ASYNYCRQNF
LSGRVLQEMA		SLKRQFTELL		SDIGFAREGL		RAREIEKRAQ		GGDGVLDATG
EEANSNAENP		KLISAMLCAA		LYPNVVQVKS		PEGKFQKTST		GAVRMQPKSA
ELKFVTKNDG		YVHIHPSSVN		YQVRHFDSPY		LLYHEKIKTS		RVFIRDCSMV
SVYPLVLFGG		GQVNVQLQRG		EFVVSLDDGW		IRFVAASHQV		AELVKELRCE
LDQLLQDKIK		NPSIDLCTCP		RGSRIISTIV		KLVTTQ

Reference

1. GRCh38: Ensembl release 89: ENSG00000163214 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035051 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57".
6. "UniProt, Q6P158" (jezik: engleski). Pristupljeno 12. 11. 2021.

Dopunska literatura

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

Vanjski linkovi