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DHX16
Pretpostavljeni pre-iRNK-prerađujući faktor ATP-ovisne RNK helikaze DHX16 jest enzim koji je kod ljudi kodiran genom DHX16.[5][6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 1.041 aminokiselina, а molekulska težina 119.264 Da.[7]
| 10 | | 20 | | 30 | | 40 | | 50 |
|---|
| MATPAGLERW | | VQDELHSVLG | | LSERHVAQFL | | IGTAQRCTSA | | EEFVQRLRDT |
| DTLDLSGPAR | | DFALRLWNKV | | PRKAVVEKPA | | RAAEREARAL | | LEKNRSYRLL |
| EDSEESSEET | | VSRAGSSLQK | | KRKKRKHLRK | | KREEEEEEEA | | SEKGKKKTGG |
| SKQQTEKPES | | EDEWERTERE | | RLQDLEERDA | | FAERVRQRDK | | DRTRNVLERS |
| DKKAYEEAQK | | RLKMAEEDRK | | AMVPELRKKS | | RREYLAKRER | | EKLEDLEAEL |
| ADEEFLFGDV | | ELSRHERQEL | | KYKRRVRDLA | | REYRAAGEQE | | KLEATNRYHM |
| PKETRGQPAR | | AVDLVEEESG | | APGEEQRRWE | | EARLGAASLK | | FGARDAASQE |
| PKYQLVLEEE | | ETIEFVRATQ | | LQGDEEPSAP | | PTSTQAQQKE | | SIQAVRRSLP |
| VFPFREELLA | | AIANHQVLII | | EGETGSGKTT | | QIPQYLFEEG | | YTNKGMKIAC |
| TQPRRVAAMS | | VAARVAREMG | | VKLGNEVGYS | | IRFEDCTSER | | TVLRYMTDGM |
| LLREFLSEPD | | LASYSVVMVD | | EAHERTLHTD | | ILFGLIKDVA | | RFRPELKVLV |
| ASATMDTARF | | STFFDDAPVF | | RIPGRRFPVD | | IFYTKAPEAD | | YLEACVVSVL |
| QIHVTQPPGD | | ILVFLTGQEE | | IEAACEMLQD | | RCRRLGSKIR | | ELLVLPIYAN |
| LPSDMQARIF | | QPTPPGARKV | | VVATNIAETS | | LTIEGIIYVL | | DPGFCKQKSY |
| NPRTGMESLT | | VTPCSKASAN | | QRAGRAGRVA | | AGKCFRLYTA | | WAYQHELEET |
| TVPEIQRTSL | | GNVVLLLKSL | | GIHDLMHFDF | | LDPPPYETLL | | LALEQLYALG |
| ALNHLGELTT | | SGRKMAELPV | | DPMLSKMILA | | SEKYSCSEEI | | LTVAAMLSVN |
| NSIFYRPKDK | | VVHADNARVN | | FFLPGGDHLV | | LLNVYTQWAE | | SGYSSQWCYE |
| NFVQFRSMRR | | ARDVREQLEG | | LLERVEVGLS | | SCQGDYIRVR | | KAITAGYFYH |
| TARLTRSGYR | | TVKQQQTVFI | | HPNSSLFEQQ | | PRWLLYHELV | | LTTKEFMRQV |
| LEIESSWLLE | | VAPHYYKAKE | | LEDPHAKKMP | | KKIGKTREEL | | G |
Funkcija
Proteini iz DEAD-kutije karakterizirani konzerviranim motivom Asp-Glu-Ala-Asp (DEAD), pretpostavljene su RNK helikaze. Oni su uključeni u brojne ćelijske procese promjena sekundarne strukture RNK, poput iniciranja translacije, jedarne i mitohondrijske prerade i sastavljanja ribosoma i splajsosoma. Na osnovu njihovih obrazaca distribucije, vjeruje se da su neki članovi ove porodice uključeni u embriogenezu, spermatogenezu, ćelijski rast i diobu. Ovaj gen kodira DEAD-kutijski protein, koji je funkcionalni homolog proteina fisionog kvasca Prp8, uključen u napredovanje ćelijskog ciklusa. Ovaj gen je mapiran u MHC regiji na heomosomu 6, sekvenca p21.3, regiji u kojoj su povezani mnogi geni malignih, genetičkih i autoimunskih bolesti.[6]
Reference
- ^ a b c ENSG00000206486, ENSG00000233418, ENSG00000231377, ENSG00000227222, ENSG00000204560, ENSG00000233049, ENSG00000226171 GRCh38: Ensembl release 89: ENSG00000233561, ENSG00000206486, ENSG00000233418, ENSG00000231377, ENSG00000227222, ENSG00000204560, ENSG00000233049, ENSG00000226171 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024422 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Imamura O, Saiki K, Tani T, Ohshima Y, Sugawara M, Furuichi Y (Jun 1998). "Cloning and characterization of a human DEAH-box RNA helicase, a functional homolog of fission yeast Cdc28/Prp8". Nucleic Acids Res. 26 (9): 2063–8. doi:10.1093/nar/26.9.2063. PMC 147520. PMID 9547260.
- ^ a b "Entrez Gene: DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16".
- ^ "UniProt, O60231" (jezik: engleski). Pristupljeno 1. 10. 2021.
Dopunska literatura
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
- Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
Vanjski linkovi
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