DDX56

DDX56
Identifikatori
Aliasi	DDX56
Vanjski ID-jevi	OMIM: 608023 MGI: 1277172 HomoloGene: 6498 GeneCards: DDX56
Lokacija gena (čovjek) Hrom. Hromosom 7 (čovjek)[1] Bend 7p13 Početak 44,565,804 bp[1] Kraj 44,575,051 bp[1]
Lokacija gena (miš) Hrom. Hromosom 11 (miš)[2] Bend 11 A1|11 3.94 cM Početak 6,208,919 bp[2] Kraj 6,217,772 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • nucleotide binding • hydrolase activity • ATP binding • GO:0008026 helicase activity • nucleic acid binding • vezivanje sa RNK Ćelijska komponenta • membrana • jedro • Jedarce • citoplazma Biološki proces • rRNA processing • RNA secondary structure unwinding • ribosome biogenesis • positive regulation of neuron projection development Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	54606	52513
Ensembl	ENSG00000136271	ENSMUSG00000004393
UniProt	Q9NY93	Q9D0R4
RefSeq (mRNK)	NM_019082 NM_001257189	NM_026538
RefSeq (bjelančevina)	NP_001244118 NP_061955	NP_080814
Lokacija (UCSC)	Chr 7: 44.57 – 44.58 Mb	Chr 11: 6.21 – 6.22 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Vjerovatna ATP-ovisna RNK-helikaza DDX56 jest enzim koji je kod ljudi kodiran genom DDX56.^[5][6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 547 aminokiselina, а molekulska težina 61.590 Da.^[7]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MEDSEALGFE		HMGLDPRLLQ		AVTDLGWSRP		TLIQEKAIPL		ALEGKDLLAR
ARTGSGKTAA		YAIPMLQLLL		HRKATGPVVE		QAVRGLVLVP		TKELARQAQS
MIQQLATYCA		RDVRVANVSA		AEDSVSQRAV		LMEKPDVVVG		TPSRILSHLQ
QDSLKLRDSL		ELLVVDEADL		LFSFGFEEEL		KSLLCHLPRI		YQAFLMSATF
NEDVQALKEL		ILHNPVTLKL		QESQLPGPDQ		LQQFQVVCET		EEDKFLLLYA
LLKLSLIRGK		SLLFVNTLER		SYRLRLFLEQ		FSIPTCVLNG		ELPLRSRCHI
ISQFNQGFYD		CVIATDAEVL		GAPVKGKRRG		RGPKGDKASD		PEAGVARGID
FHHVSAVLNF		DLPPTPEAYI		HRAGRTARAN		NPGIVLTFVL		PTEQFHLGKI
EELLSGENRG		PILLPYQFRM		EEIEGFRYRC		RDAMRSVTKQ		AIREARLKEI
KEELLHSEKL		KTYFEDNPRD		LQLLRHDLPL		HPAVVKPHLG		HVPDYLVPPA
LRGLVRPHKK		RKKLSSSCRK		AKRAKSQNPL		RSFKHKGKKF		RPTAKPS

Funkcija

Ovaj gen kodira člana proteinske porodice DEAD-kutija. Proteini iz ove kutije, karakterizirani konzerviranim motivom Asp-Glu-Ala-Asp (DEAD), su pretpostavljene RNK-helikaze. Oni su uključeni u brojne ćelijske procese koji uključuju promjenu sekundarne strukture RNK, kao što su inicijacija translacije, jedarna i mitohondrijska prerada, te sklapanje ribosoma i splajsosoma. Na osnovu njihovih obrazaca distribucije, vjeruje se da su neki članovi ove porodice uključeni u embriogenezu, spermatogenezu i ćelijski rast i diobu. Protein kodiran ovim genom pokazuje ARPaznu aktivnost u prisustvu polinukleotida i asocira na nukleoplazmatske 65S preribosomske čestice. Ovaj gen može biti uključen u sintezu ribosoma, najvjerovatnije tokom sastavljanja velike 60S ribosomske podjedinice.^[6]

Reference

1. GRCh38: Ensembl release 89: ENSG00000136271 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004393 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zirwes RF, Eilbracht J, Kneissel S, Schmidt-Zachmann MS (Jul 2000). "A Novel Helicase-Type Protein in the Nucleolus: Protein NOH61". Mol Biol Cell. 11 (4): 1153–67. doi:10.1091/mbc.11.4.1153. PMC 14838. PMID 10749921.
6. "Entrez Gene: DDX56 DEAD (Asp-Glu-Ala-Asp) box polypeptide 56".
7. "UniProt, Q9NY93" (jezik: eng). Pristupljeno 24. 9. 2021.

Dopunska literatura

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Valdez BC, Yang H, Hong E, Sequitin AM (2002). "Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs". Gene. 284 (1–2): 53–61. doi:10.1016/S0378-1119(01)00888-5. PMID 11891046.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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