CRYZ

CRYZ
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1YB5
Identifikatori
Aliasi	CRYZ
Vanjski ID-jevi	OMIM: 123691 MGI: 88527 HomoloGene: 133907 GeneCards: CRYZ
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1p31.1 Početak 74,705,482 bp[1] Kraj 74,733,408 bp[1]
Lokacija gena (miš) Hrom. Hromosom 3 (miš)[2] Bend 3|3 H4 Početak 154,596,711 bp[2] Kraj 154,623,182 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • oxidoreductase activity • vezivanje iona cinka • NADPH binding • NADPH:quinone reductase activity • NADH binding • vezivanje sa RNK • mRNA 3'-UTR binding Ćelijska komponenta • citosol • Egzosom • citoplazma Biološki proces • protein homotetramerization • xenobiotic catabolic process • Vid Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	1429	12972
Ensembl	ENSG00000116791	ENSMUSG00000028199
UniProt	Q08257	P47199
RefSeq (mRNK)	NM_001130042 NM_001130043 NM_001134759 NM_001889	NM_009968
RefSeq (bjelančevina)	NP_001123514 NP_001123515 NP_001128231 NP_001880	NP_034098 NP_001344601 NP_001344602 NP_001344603 NP_001344604 NP_001344605
Lokacija (UCSC)	Chr 1: 74.71 – 74.73 Mb	Chr 3: 154.6 – 154.62 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Kinon-oksidoreduktaza jest enzim koji je kod ljudi kodiran genom CRYZ sa hromosoma 1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 329 aminokiselina, a molekulska težina 35.207 Da.^[6]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MATGQKLMRA		VRVFEFGGPE		VLKLRSDIAV		PIPKDHQVLI		KVHACGVNPV
ETYIRSGTYS		RKPLLPYTPG		SDVAGVIEAV		GDNASAFKKG		DRVFTSSTIS
GGYAEYALAA		DHTVYKLPEK		LDFKQGAAIG		IPYFTAYRAL		IHSACVKAGE
SVLVHGASGG		VGLAACQIAR		AYGLKILGTA		GTEEGQKIVL		QNGAHEVFNH
REVNYIDKIK		KYVGEKGIDI		IIEMLANVNL		SKDLSLLSHG		GRVIVVGSRG
TIEINPRDTM		AKESSIIGVT		LFSSTKEEFQ		QYAAALQAGM		EIGWLKPVIG
SQYPLEKVAE		AHENIIHGSG		ATGKMILLL

Funkcija

Kristalini se dijele u dvije klase: specifične za taksone ili enzime i sveprisutne. Potonja klasa čini glavne proteine kičmenjaka očne leće i održava transparentnost i indeks prelamanja sočiva. Prva klasa se naziva i filogenetski ograničeni kristalini. Ovaj gen kodira kristalinski protein specifičan za takson koji ima NADPH-ovisnu aktivnost kinon-reduktaze, različitu od drugih poznatih kinon-reduktaza. Nedostaje mu aktivnost alkohol-dehidrogenaza, iako se po sličnosti smatra članom porodice alkohol-dehidrogenaza koje sadrže cink. Za razliku od drugih sisarskih vrsta, kod ljudskih sočiva ekspresija je niska. Poznato je da postoji jedan pseudogen.^[5]

Reference

1. GRCh38: Ensembl release 89: ENSG00000116791 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028199 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CRYZ crystallin, zeta (quinone reductase)".
6. "UniProt, Q08257" (jezik: engleski). Pristupljeno 23. 11. 2021.

Dopunska literatura

• Heinzmann C, Kojis TL, Gonzalez P, et al. (1995). "Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms". Genomics. 23 (2): 403–7. doi:10.1006/geno.1994.1516. PMID 7835889.
• Gonzalez P, Rao PV, Zigler JS (1994). "Organization of the human zeta-crystallin/quinone reductase gene (CRYZ)". Genomics. 21 (2): 317–24. doi:10.1006/geno.1994.1272. PMID 8088825.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Gonzalez P, Rao PV, Zigler JS (1993). "Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver". Biochem. Biophys. Res. Commun. 191 (3): 902–7. doi:10.1006/bbrc.1993.1302. PMID 8466529.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wang W, Liu LQ, Higuchi CM, Chen H (1998). "Induction of NADPH:quinone reductase by dietary phytoestrogens in colonic Colo205 cells". Biochem. Pharmacol. 56 (2): 189–95. doi:10.1016/S0006-2952(98)00141-5. PMID 9698072.
• Goenka S, Raman B, Ramakrishna T, Rao CM (2001). "Unfolding and refolding of a quinone oxidoreductase: alpha-crystallin, a molecular chaperone, assists its reactivation". Biochem. J. 359 (Pt 3): 547–56. doi:10.1042/0264-6021:3590547. PMC 1222175. PMID 11672428.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bianco NR, Perry G, Smith MA, et al. (2004). "Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage". Mol. Endocrinol. 17 (7): 1344–55. doi:10.1210/me.2002-0382. PMID 12714703.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Vanjski linkovi

• Lokacija ljudskog genoma CRYZ i stranica sa detaljima o genu CRYZ u UCSC Genome Browseru.