PROFILBARU.COM

COL16A1
Identifikatori
Aliasi	COL16A1
Vanjski ID-jevi	OMIM: 120326 MGI: 1095396 HomoloGene: 1397 GeneCards: COL16A1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	31,704,319 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	129,993,076 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• integrin binding; • GO:0001948, GO:0016582 vezivanje za proteine; • extracellular matrix structural constituent; • extracellular matrix structural constituent conferring tensile strength;
Ćelijska komponenta	• extracellular region; • collagen type XVI trimer; • collagen; • endoplasmic reticulum lumen; • GO:0005578 Vanćelijski matriks; • Vanćelijsko; • collagen-containing extracellular matrix;
Biološki proces	• cellular response to amino acid stimulus; • integrin-mediated signaling pathway; • female pregnancy; • positive regulation of focal adhesion assembly; • integrin activation; • Ćelijska adhezija; • extracellular matrix organization; • cell adhesion mediated by integrin;
	Izvori:Amigo / QuickGO
Ortolozi
	1307
	107581
	ENSG00000084636
	ENSMUSG00000040690
	Q07092
	Q8BLX7
	NM_001856
	NM_028266
	NP_001847
	NP_082542; NP_001391281; NP_001391282
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Kolagenski alfa-1(XVI) lanac jest protein koji je kod ljudi kodiran genom COL16A1 sa hromosoma 1.^[5]^[6]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 1.604 aminokiseline, a molekulska težina 157.751 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MWVSWAPGLW	LLGLWATFGH	GANTGAQCPP	SQQEGLKLEH	SSSLPANVTG
FNLIHRLSLM	KTSAIKKIRN	PKGPLILRLG	AAPVTQPTRR	VFPRGLPEEF
ALVLTLLLKK	HTHQKTWYLF	QVTDANGYPQ	ISLEVNSQER	SLELRAQGQD
GDFVSCIFPV	PQLFDLRWHK	LMLSVAGRVA	SVHVDCSSAS	SQPLGPRRPM
RPVGHVFLGL	DAEQGKPVSF	DLQQVHIYCD	PELVLEEGCC	EILPAGCPPE
TSKARRDTQS	NELIEINPQS	EGKVYTRCFC	LEEPQNSEVD	AQLTGRISQK
AERGAKVHQE	TAADECPPCV	HGARDSNVTL	APSGPKGGKG	ERGLPGPPGS
KGEKGARGND	CVRISPDAPL	QCAEGPKGEK	GESGALGPSG	LPGSTGEKGQ
KGEKGDGGIK	GVPGKPGRDG	RPGEICVIGP	KGQKGDPGFV	GPEGLAGEPG
PPGLPGPPGI	GLPGTPGDPG	GPPGPKGDKG	SSGIPGKEGP	GGKPGKPGVK
GEKGDPCEVC	PTLPEGFQNF	VGLPGKPGPK	GEPGDPVPAR	GDPGIQGIKG
EKGEPCLSCS	SVVGAQHLVS	STGASGDVGS	PGFGLPGLPG	RAGVPGLKGE
KGNFGEAGPA	GSPGPPGPVG	PAGIKGAKGE	PCEPCPALSN	LQDGDVRVVA
LPGPSGEKGE	PGPPGFGLPG	KQGKAGERGL	KGQKGDAGNP	GDPGTPGTTG
RPGLSGEPGV	QGPAGPKGEK	GDGCTACPSL	QGTVTDMAGR	PGQPGPKGEQ
GPEGVGRPGK	PGQPGLPGVQ	GPPGLKGVQG	EPGPPGRGVQ	GPQGEPGAPG
LPGIQGLPGP	RGPPGPTGEK	GAQGSPGVKG	ATGPVGPPGA	SVSGPPGRDG
QQGQTGLRGT	PGEKGPRGEK	GEPGECSCPS	QGDLIFSGMP	GAPGLWMGSS
WQPGPQGPPG	IPGPPGPPGV	PGLQGVPGNN	GLPGQPGLTA	ELGSLPIEQH
LLKSICGDCV	QGQRAHPGYL	VEKGEKGDQG	IPGVPGLDNC	AQCFLSLERP
RAEEARGDNS	EGDPGCVGSP	GLPGPPGLPG	QRGEEGPPGM	RGSPGPPGPI
GPPGFPGAVG	SPGLPGLQGE	RGLTGLTGDK	GEPGPPGQPG	YPGATGPPGL
PGIKGERGYT	GSAGEKGEPG	PPGSEGLPGP	PGPAGPRGER	GPQGNSGEKG
DQGFQGQPGF	PGPPGPPGFP	GKVGSPGPPG	PQAEKGSEGI	RGPSGLPGSP
GPPGPPGIQG	PAGLDGLDGK	DGKPGLRGDP	GPAGPPGLMG	PPGFKGKTGH
PGLPGPKGDC	GKPGPPGSTG	RPGAEGEPGA	MGPQGRPGPP	GHVGPPGPPG
QPGPAGISAV	GLKGDRGATG	ERGLAGLPGQ	PGPPGHPGPP	GEPGTDGAAG
KEGPPGKQGF	YGPPGPKGDP	GAAGQKGQAG	EKGRAGMPGG	PGKSGSMGPV
GPPGPAGERG	HPGAPGPSGS	PGLPGVPGSM	GDMVNYDEIK	RFIRQEIIKM
FDERMAYYTS	RMQFPMEMAA	APGRPGPPGK	DGAPGRPGAP	GSPGLPGQIG
REGRQGLPGV	RGLPGTKGEK	GDIGIGIAGE	NGLPGPPGPQ	GPPGYGKMGA
TGPMGQQGIP	GIPGPPGPMG	QPGKAGHCNP	SDCFGAMPME	QQYPPMKTMK
GPFG

Funkcija

Ovaj gen kodira alfa lanac kolagena tipa XVI, člana porodice kolagena FACIT (kolageni povezani s fibrilima sa prekinutim spiralama). Članovi ove porodice kolagena u vezi su sa kolagenima koji formiraju vlakna, kao što su tip I i II, i služe za održavanje integriteta vanćelijskog matriksa. Visoki nivoi kolagena tipa XVI pronađeni su u fibroblastima i keratinocitima, te u glatkim mišićima i amnionu.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000084636 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040690 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pan TC, Zhang RZ, Mattei MG, Timpl R, Chu ML (Aug 1992). "Cloning and chromosomal location of human alpha 1(XVI) collagen". Proc Natl Acad Sci U S A. 89 (14): 6565–9. Bibcode:1992PNAS...89.6565P. doi:10.1073/pnas.89.14.6565. PMC 49542. PMID 1631157.
^ ^a ^b "Entrez Gene: COL16A1 collagen, type XVI, alpha 1".
^ "UniProt, Q07092" (jezik: engleski). Pristupljeno 23. 11. 2021.

Dopunska literatura

Yamaguchi N, Kimura S, McBride OW, Hori H, Yamada Y, Kanamori T, Yamakoshi H, Nagai Y (1993). "Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments". J. Biochem. 112 (6): 856–63. doi:10.1093/oxfordjournals.jbchem.a123989. PMID 1284248.
Ratzinger S, Grässel S, Dowejko A, Reichert TE, Bauer RJ (2011). "Induction of type XVI collagen expression facilitates proliferation of oral cancer cells". Matrix Biology. 30 (2): 118–25. doi:10.1016/j.matbio.2011.01.001. PMID 21251976.
Sires UI, Dublet B, Aubert-Foucher E, van der Rest M, Welgus HG (1995). "Degradation of the COL1 domain of type XIV collagen by 92-kDa gelatinase". J. Biol. Chem. 270 (3): 1062–7. doi:10.1074/jbc.270.3.1062. PMID 7836360.
Tillet E, Mann K, Nischt R, Pan TC, Chu ML, Timpl R (1995). "Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain". Eur. J. Biochem. 228 (1): 160–8. doi:10.1111/j.1432-1033.1995.tb20245.x. PMID 7882999.
Grässel S, Timpl R, Tan EM, Chu ML (1997). "Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells". Eur. J. Biochem. 242 (3): 576–84. doi:10.1111/j.1432-1033.1996.0576r.x. PMID 9022684.
Ratzinger S, Grässel S, Dowejko A, Reichert TE, Bauer RJ (mart 2011). "Induction of type XVI collagen expression facilitates proliferation of oral cancer cells". Matrix Biology. 30 (2): 118–25. doi:10.1016/j.matbio.2011.01.001. PMID 21251976.
Kassner A, Hansen U, Miosge N, Reinhardt DP, Aigner T, Bruckner-Tuderman L, Bruckner P, Grässel S (2004). "Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils". Matrix Biol. 22 (2): 131–43. doi:10.1016/S0945-053X(03)00008-8. PMID 12782140.
Kassner A, Tiedemann K, Notbohm H, Ludwig T, Mörgelin M, Reinhardt DP, Chu ML, Bruckner P, Grässel S (2004). "Molecular structure and interaction of recombinant human type XVI collagen". J. Mol. Biol. 339 (4): 835–53. doi:10.1016/j.jmb.2004.03.042. PMID 15165854.
Eble JA, Kassner A, Niland S, Mörgelin M, Grifka J, Grässel S (2006). "Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains". J. Biol. Chem. 281 (35): 25745–56. doi:10.1074/jbc.M509942200. PMID 16754661.

Vanjski linkovi

"COL16A1 (collagen, type XVI, alpha 1)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000084636 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040690 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1631157-5] Pan TC, Zhang RZ, Mattei MG, Timpl R, Chu ML (Aug 1992). "Cloning and chromosomal location of human alpha 1(XVI) collagen". Proc Natl Acad Sci U S A. 89 (14): 6565–9. Bibcode:1992PNAS...89.6565P. doi:10.1073/pnas.89.14.6565. PMC 49542. PMID 1631157.

[entrez-6] "Entrez Gene: COL16A1 collagen, type XVI, alpha 1".

[UniProt-7] "UniProt, Q07092" (jezik: engleski). Pristupljeno 23. 11. 2021.

[1]

[2]

[3]

[4]

[5]

[6]

[7]