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CKMT1B
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1QK1
Identifikatori
Aliasi	CKMT1B
Vanjski ID-jevi	OMIM: 123290 MGI: 99441 HomoloGene: 69058 GeneCards: CKMT1B
Lokacija gena (čovjek)
Hrom.	Hromosom 15 (čovjek)
Kraj	43,604,901 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	121,194,218 bp
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • creatine kinase activity; • nucleotide binding; • transferase activity, transferring phosphorus-containing groups; • catalytic activity; • ATP binding; • kinase activity;
Ćelijska komponenta	• mitochondrial inner membrane; • membrana; • mitohondrija;
Biološki proces	• creatine metabolic process; • Fosforilacija; • phosphocreatine biosynthetic process;
	Izvori:Amigo / QuickGO
Ortolozi
	1159
	12716
	ENSG00000237289
	ENSMUSG00000000308
	P12532
	P30275
	NM_020990; NM_001375484
	NM_009897; NM_001355069
NP_001015001; NP_001308855; NP_001308856; NP_001308857; NP_001308858;
	NP_001362413; NP_066270
	NP_034027; NP_001341998
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Mitohondrijska kreatin-kinaza 1B, znana i kao CKMT1B je jedan od dva gena koji kodiraju sveprisutnu mitohondrijsku kreatin kinazu (sveprisutni mtCK ili CKMT1).^[5]

Funkcija

Mitohondrijskog kreatin-kinaza (MtCK) odgovorna je za prijenos visokoenergetskog fosfata iz mitohondrija u citosolni nosač kreatin. Pripada porodici kreatin-kinaznih izoenzima. Postoji kao dva izoenzima, sarkomerni MtCK (CKMT2) i sveprisutni MtCK, kodirana odvojenim genima. Mitohondrijska kreatin-kinaza javlja se u dva različita oligomerna oblika: dimerima i oktamerima, za razliku od isključivo dimernih izoenzima citosolne kreatin-kinaze. Sveprisutna mitohondrijska kreatin-kinaza ima 80% homologije sa kodirajućim egzonima sarkomerne mitohondrijske kreatin-kinaze. Identificirana su dva gena koja se nalaze međusobno blizu, na hromosomu 15 (CKMT1A i CKMT1B (ovaj gen)) koji kodiraju identične proteine mitohondrijske kreatin-kinaze.^[5]

Klinički značaj

Mnogi maligni karcinomi sa lošom prognozom pokazali su prekomjernu ekspresiju sveprisutne mitohondrijske kreatin-kinaze; ovo može biti povezano s velikim prometom energije i neuspjehom apoptoznog uklanjanja ćelija karcinoma.^[5]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000237289 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000308 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c "Entrez Gene: CKMT1B creatine kinase, mitochondrial 1B".

Vanjski linkovi

Lokacija ljudskog genoma CKMT1B i stranica sa detaljima o genu CKMT1B u UCSC Genome Browseru.

Dopunska literatura

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Haas RC, Strauss AW (1990). "Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzymes". J. Biol. Chem. 265 (12): 6921–7. PMID 2324105.
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Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
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Eder M, Fritz-Wolf K, Kabsch W, Wallimann T, Schlattner U (2000). "Crystal structure of human ubiquitous mitochondrial creatine kinase". Proteins. 39 (3): 216–25. doi:10.1002/(SICI)1097-0134(20000515)39:3<216::AID-PROT40>3.0.CO;2-#. PMID 10737943.
Schlattner U, Wallimann T (2000). "Octamers of mitochondrial creatine kinase isoenzymes differ in stability and membrane binding". J. Biol. Chem. 275 (23): 17314–20. doi:10.1074/jbc.M001919200. PMID 10748055.
Schlattner U, Dolder M, Wallimann T, Tokarska-Schlattner M (2002). "Mitochondrial creatine kinase and mitochondrial outer membrane porin show a direct interaction that is modulated by calcium". J. Biol. Chem. 276 (51): 48027–30. doi:10.1074/jbc.M106524200. PMID 11602586.
Schlattner U, Wallimann T (2002). "A quantitative approach to membrane binding of human ubiquitous mitochondrial creatine kinase using surface plasmon resonance". J. Bioenerg. Biomembr. 32 (1): 123–31. doi:10.1023/A:1005576831968. PMID 11768757.
Schlattner U, Möckli N, Speer O, Werner S, Wallimann T (2002). "Creatine kinase and creatine transporter in normal, wounded, and diseased skin". J. Invest. Dermatol. 118 (3): 416–23. doi:10.1046/j.0022-202x.2001.01697.x. PMID 11874479.