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Mitohondrijski ATP sintazno-spregnuti faktor 6 (F6)
Mitohondrijski ATP sintazno-spregnuti faktor 6 (F6)
	Struktura rastvora podjedinice f6 iz periferne regije drške ATP sintaze iz mitohondrija goveđeg srca
Identifikatori
Simbol	ATP-synt F6

ATP5PF
Identifikatori
Aliasi	ATP5PF
Vanjski ID-jevi	OMIM: 603152 MGI: 107777 HomoloGene: 1272 GeneCards: ATP5PF
Lokacija gena (čovjek)
Hrom.	Hromosom 21 (čovjek)
Kraj	25,735,673 bp
Lokacija gena (miš)
Hrom.	Hromosom 16 (miš)
Kraj	84,632,513 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• transporter activity; • proton transmembrane transporter activity; • GO:0022891 transmembrane transporter activity; • ATPase activity; • GO:0032403 protein-containing complex binding;
Ćelijska komponenta	• mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); • proton-transporting ATP synthase complex, coupling factor F(o); • membrana; • mitochondrial proton-transporting ATP synthase complex; • mitochondrial inner membrane; • mitohondrija; • Vanćelijsko; • cell surface;
Biološki proces	• ATP synthesis coupled proton transport; • ion transport; • substantia nigra development; • ATP metabolic process; • mitochondrial ATP synthesis coupled proton transport; • ATP biosynthetic process; • cristae formation; • GO:0015915 transport; • positive regulation of heart rate; • response to muscle activity; • negative regulation of prostaglandin secretion; • positive regulation of blood pressure; • negative regulation of arachidonic acid secretion;
	Izvori:Amigo / QuickGO
Ortolozi
	522
	11957
	ENSG00000154723
	ENSMUSG00000022890
	P18859
	P97450
NM_001003696; NM_001003697; NM_001003701; NM_001003703; NM_001685;
	NM_001320266; NM_001320267
NM_016755; NM_001302213; NM_001302214; NM_001302215; NM_001302216;
	NM_001358499; NM_001358500
NP_001003696; NP_001003697; NP_001003701; NP_001003703; NP_001307195;
	NP_001307196; NP_001676
NP_001289142; NP_001289143; NP_001289144; NP_001289145; NP_058035;
	NP_001345428; NP_001345429
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Mitohondrijski ATP sintazno-spregnuti faktor 6 jest enzim koji je kod ljudi kodiran genom ATP5PF sa hromosoma 21.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 108 aminokiselina, a molekulska težina 12.588 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MILQRLFRFS	SVIRSAVSVH	LRRNIGVTAV	AFNKELDPIQ	KLFVDKIREY
KSKRQTSGGP	VDASSEYQQE	LERELFKLKQ	MFGNADMNTF	PTFKFEDPKF
EVIEKPQA

Funkcija

Mitohondrijska ATP-sintaza katalizira sintezu ATP-a, koristeći elektrohemijski gradijent protona preko unutrašnje membrane tokom oksidativne fosforilacije. Sastoji se od dva povezana kompleksa sa više podjedinica: rastvorljivo katalitsko jezgro, F₁ i komponenta koja se proteže kroz membranu , F_O, koji sadrže protonski kanal. Kompleks F₁ sastoji se od pet različitih podjedinica (alfa, beta, gama, delta i epsilon), sastavljenih u omjeru od 3 alfa, 3 beta i po jednog predstavnika ostala trz. F _O ima devet podjedinica (a, b, c, d, e, f, g, F6 i 8). Ovaj gen kodira F6 podjedinicu kompleksa F_O, neophodnu za nterakcijeF₁ i F_O. Za ovaj gen identificirane su alternativno prerađene varijante transkripta koje kodiraju različite izoforme.^[7]

Podjedinica F6 je dio periferne drške koja povezuje komplekse F₁ i F_O i koja djeluje kao stator, kako bi spriječila određene podjedinice da rotiraju sa centralnim rotirajućim element. Periferna drškaka razlikuje se u sastavu podjedinica između mitohondijskih, hloroplastnih i bakterijskih F-ATPaza. U mitohondrijAma, periferna drškaka sastoji se od po jedne kopije podjedinica OSCP (oligomicin senzitivni vezni protein), F6, b i d.^[8] U bakterijskoj ili hloroplastnoj F-ATPazi, ne postoji homolog[ podjedinice F6, čije se periferne drške sastoje od jedne kopije podjedinice delta (homologne OSCP) i dvije kopije podjedinice b u bakterijama, ili jedne kopije svake od podjedinica b i b' u hloroplastima i fotosintetskim bakterijama.

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154723 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022890 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Higuti T, Tsurumi C, Kawamura Y, Tsujita H, Osaka F, Yoshihara Y, Tani I, Tanaka K, Ichihara A (Jul 1991). "Molecular cloning of cDNA for the import precursor of human coupling factor 6 of H(+)-ATP synthase in mitochondria". Biochemical and Biophysical Research Communications. 178 (2): 793–9. doi:10.1016/0006-291X(91)90178-A. PMID 1830479.
^ Javed AA, Ogata K, Sanadi DR (Jan 1991). "Human mitochondrial ATP synthase: cloning cDNA for the nuclear-encoded precursor of coupling factor 6". Gene. 97 (2): 307–10. doi:10.1016/0378-1119(91)90068-M. PMID 1825642.
^ ^a ^b ^c "Entrez Gene: ATP5PF ATP synthase peripheral stalk subunit F6".
^ Carbajo RJ, Kellas FA, Runswick MJ, Montgomery MG, Walker JE, Neuhaus D (Aug 2005). "Structure of the F1-binding domain of the stator of bovine F1Fo-ATPase and how it binds an alpha-subunit". Journal of Molecular Biology. 351 (4): 824–38. doi:10.1016/j.jmb.2005.06.012. PMID 16045926.

Dopunska literatura

Kinosita K, Yasuda R, Noji H (2003). "F1-ATPase: a highly efficient rotary ATP machine". Essays in Biochemistry. 35: 3–18. doi:10.1042/bse0350003. PMID 12471886.
Oster G, Wang H (Mar 2003). "Rotary protein motors". Trends in Cell Biology. 13 (3): 114–21. doi:10.1016/S0962-8924(03)00004-7. PMID 12628343.
Leyva JA, Bianchet MA, Amzel LM (2003). "Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review)". Molecular Membrane Biology. 20 (1): 27–33. doi:10.1080/0968768031000066532. PMID 12745923. S2CID 218895820.
Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R (Dec 1992). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669. S2CID 23518983.
Yan WL, Lerner TJ, Haines JL, Gusella JF (Nov 1994). "Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3)". Genomics. 24 (2): 375–7. doi:10.1006/geno.1994.1631. PMID 7698763.
Elston T, Wang H, Oster G (Jan 1998). "Energy transduction in ATP synthase". Nature. 391 (6666): 510–3. Bibcode:1998Natur.391..510E. doi:10.1038/35185. PMID 9461222. S2CID 4406161.
Webster KA, Oliver NA, Wallace DC (Mar 1982). "Assignment of an oligomycin-resistance locus to human chromosome 10". Somatic Cell Genetics. 8 (2): 223–44. doi:10.1007/BF01538679. PMID 9732751. S2CID 12445064.
Wang H, Oster G (Nov 1998). "Energy transduction in the F1 motor of ATP synthase". Nature. 396 (6708): 279–82. Bibcode:1998Natur.396..279W. doi:10.1038/24409. PMID 9834036. S2CID 4424498.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Osanai T, Nakamura M, Sasaki S, Tomita H, Saitoh M, Osawa H, Yamabe H, Murakami S, Magota K, Okumura K (Dec 2003). "Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease". Kidney International. 64 (6): 2291–7. doi:10.1046/j.1523-1755.2003.00334.x. PMID 14633154.
Cross RL (Jan 2004). "Molecular motors: turning the ATP motor". Nature. 427 (6973): 407–8. Bibcode:2004Natur.427..407C. doi:10.1038/427407b. PMID 14749816. S2CID 52819856.
Jacobs LJ, de Coo IF, Nijland JG, Galjaard RJ, Los FJ, Schoonderwoerd K, Niermeijer MF, Geraedts JP, Scholte HR, Smeets HJ (Mar 2005). "Transmission and prenatal diagnosis of the T9176C mitochondrial DNA mutation". Molecular Human Reproduction. 11 (3): 223–8. CiteSeerX 10.1.1.603.8165. doi:10.1093/molehr/gah152. PMID 15709156.

Vanjski linkovi

Lokacija ljudskog genoma ATP5PF i stranica sa detaljima o genu ATP5PF u UCSC Genome Browseru.

Ovaj članak uključuje tekst iz javnog domena Pfam i InterPro: IPR008387

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154723 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022890 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1830479-5] Higuti T, Tsurumi C, Kawamura Y, Tsujita H, Osaka F, Yoshihara Y, Tani I, Tanaka K, Ichihara A (Jul 1991). "Molecular cloning of cDNA for the import precursor of human coupling factor 6 of H(+)-ATP synthase in mitochondria". Biochemical and Biophysical Research Communications. 178 (2): 793–9. doi:10.1016/0006-291X(91)90178-A. PMID 1830479.

[pmid1825642-6] Javed AA, Ogata K, Sanadi DR (Jan 1991). "Human mitochondrial ATP synthase: cloning cDNA for the nuclear-encoded precursor of coupling factor 6". Gene. 97 (2): 307–10. doi:10.1016/0378-1119(91)90068-M. PMID 1825642.

[entrez-7] "Entrez Gene: ATP5PF ATP synthase peripheral stalk subunit F6".

[pmid16045926-8] Carbajo RJ, Kellas FA, Runswick MJ, Montgomery MG, Walker JE, Neuhaus D (Aug 2005). "Structure of the F1-binding domain of the stator of bovine F1Fo-ATPase and how it binds an alpha-subunit". Journal of Molecular Biology. 351 (4): 824–38. doi:10.1016/j.jmb.2005.06.012. PMID 16045926.

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