SR 105 heads east as a four-lane divided highway that has a partial cloverleaf interchange with US 60 (Warwick Boulevard); the interchange includes a flyover ramp from westbound US 60 to westbound SR 105. The state highway crosses Lee Hall Reservoir and CSX's Peninsula Subdivision railroad line. East of the railroad, SR 105 has a cloverleaf interchange with I-64 and an intersection with SR 143 (Jefferson Avenue). SR 143 is used as an intermediary for the ramps from westbound I-64 to eastbound SR 105 and from westbound SR 105 to westbound I-64.
SR 105 continues east along the southern edge of Newport News Park before entering York County, where the highway passes through a forested area with scattered residential subdivisions. SR 105 reaches its eastern terminus at US 17 (George Washington Memorial Highway) between Yorktown to the north and Grafton to the south. Fort Eustis Boulevard continues east as SR 1050 to the named highway's present eastern terminus at SR 634 (Old York Hampton Highway).[1][2]
In late 2009 the Virginia Department of Transportation began a widening project of SR 105 between Jefferson Avenue in Newport News and US 17 in York County. The road was widened from two to four lanes with a raised median. Construction was completed in Spring 2012.[3]