Vijay Kumar (molecular biologist)

Vijay Kumar
Born	(1954-11-07) 7 November 1954 (age 70) Sasaram, Bihar, India
Nationality	Indian
Alma mater	Tilka Manjhi Bhagalpur University Magadh University AIIMS Delhi Louis Pasteur University
Known for	Studies on reproductive immunology
Awards	1997 Shanti Swarup Bhatnagar Prize
Scientific career
Fields	Molecular biology
Institutions	AIIMS Delhi International Centre for Genetic Engineering and Biotechnology

Vijay Kumar (born 7 November 1954) is an Indian molecular biologist, virologist and an honorary scientist at the International Centre for Genetic Engineering and Biotechnology. Known for his research in hepatology, Kumar is an elected fellow of National Academy of Sciences, India, National Academy of Medical Sciences, and National Academy of Agricultural Sciences as well as a J. C. Bose National Fellow of the Department of Biotechnology. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 1997.^{[1][note 1]}

Biography

AIIMS Delhi

Vijay Kumar was born on 7 November 1954 at Sasaram, a place known for its quarries, in Rohtas district in the Indian state of Bihar.^[2] His early college education was at Sahibganj College of Tilka Manjhi Bhagalpur University from where he completed his BSc (Hons) in zoology in 1972 and earned an MSc from Magadh University in 1975. Subsequently, he joined the All India Institute of Medical Sciences, Delhi as a junior research fellow and continued there for his doctoral studies as a Lady Tata Senior Research Scholar to secure a PhD in 1984 for his thesis, Molecular interactions of progesterone with its receptor in human uterus.^[3] He started his career the same year by joining AIIMS faculty as a junior research officer at the department of biophysics but took a sabbatical to move to Institut de Chimie Biologique, Strasbourg as an exchange scholar of Louis Pasteur University and did his post-doctoral studies till 1988. Returning to India, he joined International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi as a research scientist where he served out his regular career till his superannuation in 2014. During this period, he held various positions such as senior research scientist (1998–2001), staff research scientist (2002–13), staff scientist (2013–14) and headed the Virology Group from 2013 to 2014. Post-retirement, he continues his association with ICGEB as an emeritus scientist and as J. C. Bose National Fellow.^[4]

Legacy

The genome organisation of HBV; the genes overlap. ORF X, in yellow, encodes HBx.

Vijay Kumar focused his research on the assembly, cloning and expression of genes and on the role played by steroid hormone receptors as well as oncogenic viruses in producing cancer cells.^[4] He has done pioneering research on Hepatitis B virus^[5] and his studies widened the understanding of the trans-activating domain of the HBx protein.^[6] He contributed in developing a protocol for assembling multiepitope protein gene which assisted in the studies of the immunobiology of the virus. His research collaboration with Debi Prasad Sarkar assisted him to demonstrate for the first time that HBx protein stimulated Mitogen-activated signaling cascades in vivo.^[7] His research has been documented and cited in texts and articles^{[8][9] [note 2]} and he has contributed chapters to books published by others.^[10][11]

Kumar is a member of the Institutional Ethics Review Board (IERB-JNU) of the Jawaharlal Nehru University^[12] and was a member of the Advisory Committee for Shanti Swarup Bhatnagar Prize for the years, 2005, 2011 and 2014.^[4] He served as a principal investigator for a number of projects by Department of Science and Technology^[13] and Department of Biotechnology.^[14][15] The invited lectures or key note addresses delivered by him include the presentation on Epigenetic control of origin licensing during mammalian DNA replication at the Indian Science Congress of 2012^[16] among others.^[17][18]

Awards and honors

Kumar won a number of prizes during his academic studies which included the Kul Prize for Best Science graduate of Bhagalpur University (1972), DPI Merit Scholarship during 1973–75 and the Gold Medal of Magadh University in 1977 for standing first in MSc examination.^[4] The Council of Scientific and Industrial Research awarded him Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards in 1997.^[19] The list of research fellowships held by him features Lady Tata Senior Research Scholarship of Lady Tata Memorial Trust (1982–84), Indo-French Scientific and Cultural Exchange Fellowship (1984–85) and the J. C. Bose National Fellowship of the Department of Biotechnology in 2013.^[3] He received the Gold Medal of the Zoological Society of India in 1998.^[4] In 2002 he was elected as a fellow by the National Academy of Sciences, India.^[20] The National Academy of Agricultural Sciences elected him as a fellow in 2004^[21] and he became a fellow of the National Academy of Medical Sciences in 2013.^[22] The award orations delivered by him include the 2013 Ramniklal J. Kinarivala Oration Award of Gujarat Cancer Society.^[4]

Selected bibliography

• Grace Fatima, Ganeshan Mathan, Vijay Kumar (2012). "The HBx protein of hepatitis B virus regulates the expression, intracellular distribution and functions of ribosomal protein S27a". Journal of General Virology. 93 (4): 706–715. doi:10.1099/vir.0.035691-0. PMID 22158882.
• Nagisa Nosrati, Neetu R. Kapoor, Vijay Kumar (2014). "Combinatorial action of transcription factors orchestrates cell cycle-dependent expression of the ribosomal protein genes and ribosome biogenesis". The FEBS Journal. 281 (10): 2339–2352. doi:10.1111/febs.12786. PMID 24646001. S2CID 205134793.
• Kaveri Sidhu, Vijay Kumar (2015). "c-ETS transcription factors play an essential role in the licensing of human MCM4 origin of replication". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1849 (11): 1319–1328. doi:10.1016/j.bbagrm.2015.09.005. PMID 26365772.
• Pallavi Rajput, Surendra K Shukla, Vijay Kumar (2015). "The HBx oncoprotein of hepatitis B virus potentiates cell transformation by inducing c-Myc-dependent expression of the RNA polymerase I transcription factor UBF". Virology Journal. 12 (1): 62. doi:10.1186/s12985-015-0293-5. PMC 4424551. PMID 25890091.
• Richa Ahuja, Neetu Rohit Kapoor, Vijay Kumar (2015). "The HBx oncoprotein of Hepatitis B virus engages Nucleophosmin to promote rDNA transcription and cellular proliferation". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1853 (8): 1783–1795. doi:10.1016/j.bbamcr.2015.04.012. PMID 25918010.

See also

• Epitope mapping
• Viral protein

Notes

1. Long link – please select award year to see details
2. Please see Selected bibliography section

References

1. "View Bhatnagar Awardees". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 12 November 2016.
2. "Profile on NAAS". National Academy of Agricultural Sciences. 2017.
3. "Ex PhDs of the department with year of award & thesis titles". AIIMS, Delhi. 2017.
4. "Faculty profile". International Centre for Genetic Engineering and Biotechnology. 2017.
5. "Brief Profile of the Awardee". Shanti Swarup Bhatnagar Prize. 2017.
6. "Handbook of Shanti Swarup Bhatnagar Prize Winners" (PDF). Council of Scientific and Industrial Research. 1999. p. 71.
7. D. P. Burma; Maharani Chakravorty (2011). From Physiology and Chemistry to Biochemistry. Pearson Education India. pp. 146–. ISBN 978-81-317-3220-5.
8. "On ResearchGate". 2017.
9. "A DIRECT GRASS ROOT EXPERIENCE FROM BASIC BIOLOGICAL SCIENCE TO APPLIED POTENTIAL LEADING TO PATENTING/COMMERCIALIZATION" (PDF). IIM Ahmedabad. 2017.
10. Manfred Gossen; Jörg Kaufmann; Steven J. Triezenberg (6 December 2012). Transcription Factors. Springer Science & Business Media. pp. 377–. ISBN 978-3-642-18932-6.
11. Dr. Shahid Jameel; Luis Villareal (1 January 2000). Advances in Animal Virology: Papers Presented at the Second ICGEB-UCI Virology Symposium, New Delhi, November 1998. Science Publishers. ISBN 978-1-57808-094-6.
12. "Institutional Ethics Review Board". Jawaharlal Nehru University. 2017. Archived from the original on 21 March 2017.
13. "List of Approved Projects during year 2010–11" (PDF). Department of Science and Technology. 2011.
14. "Studies on the molecular mechanisms of deregulation of mammalian DNA replication by viral oncoproteins". Help Biotech. 2012.
15. "Evaluation of the oncogenic potential of signal transduction domains of the Hepatitis-B virus X protein in a transgenic environment". Department of Biotechnology. 2017.
16. "Indian Science Congress of 2012" (PDF). Indian Science Congress. 2012.
17. "Events of the Faculty of Life Sciences & Biotechnology". South Asian University. 2017.
18. "First National Conference on Mapping the "Materials Genome"" (PDF). Shiv Nadar University. 2013. Archived from the original (PDF) on 19 May 2017. Retrieved 20 March 2017.
19. "Medical Sciences". Council of Scientific and Industrial Research. 2017. Archived from the original on 24 February 2013.
20. "NASI fellows". National Academy of Sciences, India. 2017.
21. "NAAS Fellows". National Academy of Agricultural Sciences. 2017.
22. "NAMS Fellows" (PDF). National Academy of Medical Sciences. 2017.

External links

• "Epigenetic control in DNA replication". Nature India. Nature Asia. 30 July 2012. doi:10.1038/nindia.2012.113.