The construction of Uttaradit Hospital started in 1940 during World War II, initiated by Khun Phra Samak Samoson, then governor of Uttaradit. The hospital opened on 12 April 1951.[2] In 1999, the hospital made an agreement to train medical students and act as a clinical teaching hospital for the Faculty of Medicine, Naresuan University and about 30 students are trained here annually under the Collaborative Project to Increase Production of Rural Doctors (CPIRD) program.[3]