Following the setup of sukhaphiban in Nakhon Ratchasima Province under the reign of King Chulalongkorn, two hospitals were built in the local area:
Sukhaphiban 1 Hospital treating general patients at Pho Klang Subdistrict
Sukhaphiban 2 Hospital treating patients with infectious diseases at Suan Mon Subdistrict
Sukhaphiban 1 Hospital was then merged into Sukhaphiban 2 Hospital and renamed 'Suan Mon Hospital'.
On 1 February 1935, Suan Mon Hospital was transferred from the responsibility of Sukhaphiban Hospitals Organisation to Nakhon Ratchasima City Municipality and the hospital was renamed 'Nakhon Ratchasima City Municipality Hospital'. On 1 September 1954, operations were transferred to the Ministry of Public Health and renamed 'Nakhon Ratchasima City Hospital', and was categorised as a provincial hospital. In 1974, the hospital was re-categorised as a regional hospital. On 5 September 1981, the hospital was renamed by the Ministry of Public Health as 'Maharat Nakhon Ratchasima Hospital' in honour of King Bhumibol Adulyadej.[6]