In 2003, Amy Loughren is a single mother and nurse working in the intensive care unit (ICU) at Parkfield Memorial Hospital in New Jersey, who is suffering from cardiomyopathy, unbeknownst to anyone at the hospital, and fears dismissal. Having no health insurance, Amy has no other choice than to remain working for another four months, in order to acquire the insurance to afford a heart transplant. The hospital recruits experienced nurse Charles Cullen to help her work the night shifts, and they quickly become good friends. Charlie discovers her condition and empathetically agrees to keep it a secret.
When an elderly patient named Ana Martinez, who was being looked after by Amy and Charlie, suddenly dies, the hospital's administrative board contacts the state police, represented by detectives Danny Baldwin and Tim Braun. However, the board, led by risk manager Linda Garran, quickly downplays it, claiming the death was unintentional and that the reason for reporting it was simply to abide by health protocol. Baldwin is immediately wary of the situation, noting they reported Martinez's death seven weeks after its occurrence after the body had been cremated. He fixates on Charlie and discovers he had been convicted of minor charges in 1995. They question Amy who notices that insulin had been administered to Martinez, demonstrated by her decreased C peptide levels, despite her being a non-diabetic. She is questioned about Charlie's character but Amy is quick to challenge them. She doesn't want to be involved in the situation and clearly trusts her colleague.
Baldwin and Braun attempt to contact the hospitals where Charlie had worked previously but none are willing to cooperate. Parkfield finally shares its investigation with the police, but Baldwin notices that it is fragmentary, leading him to snap at Garran, causing him and Braun to be banned from the hospital. Meanwhile, after Kelly Anderson, another ICU patient suffers a seizure and inexplicably dies, Amy discovers insulin had also been administered to her the night before. Suspicious, she contacts an old friend, Lori, a fellow nurse who worked with Charlie at a different hospital. Lori reveals that during Charlie's employment, the ward he was assigned to dealt with numerous sudden deaths, with the discovery of insulin in several of them. Shocked, Amy raids Parkfield's storage, discovering holes in several IV bags, indicating they had been contaminated. During her discovery, she collapses and ends up in the ER.
Finally convinced of Charlie's complicity, she alerts the detectives. They convince Kelly's husband to exhume her body in order to perform an autopsy; it reveals a dual combination of insulin and digoxin led to her death. Meanwhile, Garran fires Charlie under the pretext of minor discrepancies found in his résumé. In an attempt to entice Charlie into disclosing his actions, Baldwin and Braun have Amy arrange a meeting with him, but he reacts aggressively when she asks about his dismissal from Parkfield.
The police arrest and hold him, but are unable to get him to confess on record. Unwilling to see him released, Amy volunteers to talk to Charlie; she has a warm conversation with him, and asks that he tells the truth. After some deliberation, Charlie confesses, stating that he simply "did it". When Amy asks why, he says, "they didn't stop me."
A textual epilogue reveals Charlie was sentenced to 18 consecutive life sentences for the murders of 29 patients but that the actual number could be as high as 400. Amy underwent the heart surgery she needed, and now lives in Florida with her daughters and grandchildren.
No further development on the film was announced until February 2020. Chastain and Redmayne were confirmed to star, with Lionsgate no longer involved.[5]Netflix entered negotiations to buy the film's worldwide distribution rights for $25 million.[6]
On the review aggregator website Rotten Tomatoes, 74% of 168 critics' reviews are positive, with an average rating of 6.7/10. The website's consensus reads: "The Good Nurse is hobbled by stilted dialogue and unrealistic story elements, but those issues are offset by strong work from a pair of talented leads."[10]Metacritic, which uses a weighted average, assigned the film a score of 65 out of 100, based on 38 critics, indicating "generally favorable" reviews.[11]
The Good Nurse was the most-viewed film on Netflix on October 27, 2022, the day after its release. In its first week, it debuted at number one on Netflix's Top 10 with 68.31 million viewing hours with it being Top 10 in 93 countries.[12][13] The next week, it dropped to second, behind Enola Holmes 2, having received 36.78 million viewing hours.[14]