Holweni made her senior debut on 12 May 2019 in a 0–3 friendly loss to the United States. On 9 November 2020, Holweni scored five goals in the team's 7–0 win over Comoros in Group A of the 2020 COSAFA Women's Championship.[4] South Africa finished at the top of their group and advanced to the knockout stage. They won the championship and Holweni was named top goal scorer with 8 goals.