RNF14

RNF14
Identifiers
Aliases	RNF14, ARA54, HFB30, TRIAD2, HRIHFB2038, ring finger protein 14
External IDs	OMIM: 605675; MGI: 1929668; HomoloGene: 129170; GeneCards: RNF14; OMA:RNF14 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 141,958,328 bp[1] End 141,990,292 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B3|18 20.2 cM Start 38,417,590 bp[2] End 38,450,902 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell oocyte secondary oocyte right testis right adrenal cortex left testis Achilles tendon islet of Langerhans rectum left adrenal gland Top expressed in CA3 field perirhinal cortex entorhinal cortex dorsal tegmental nucleus central gray substance of midbrain superior colliculus subiculum ventral tegmental area inferior colliculi Medulla Oblongata More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin protein ligase activity transcription coactivator activity metal ion binding ubiquitin-protein transferase activity ubiquitin-like protein transferase activity protein binding androgen receptor binding ubiquitin conjugating enzyme binding transferase activity Cellular component cytoplasm ubiquitin ligase complex nucleus cytosol Biological process androgen receptor signaling pathway regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II protein polyubiquitination transcription, DNA-templated positive regulation of transcription, DNA-templated protein ubiquitination regulation of androgen receptor signaling pathway positive regulation of proteasomal ubiquitin-dependent protein catabolic process signal transduction ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9604 56736 Ensembl ENSG00000013561 ENSMUSG00000060450 UniProt Q9UBS8 Q9JI90 RefSeq (mRNA) NM_001201365 NM_004290 NM_183398 NM_183399 NM_183400 NM_183401 NM_001164621 NM_001164622 NM_020012 NM_001361264 NM_001361265 NM_001361266 NM_001361267 NM_001361268 NM_001361269 RefSeq (protein) NP_001188294 NP_004281 NP_899645 NP_899646 NP_899647 NP_899648 NP_001158093 NP_001158094 NP_064396 NP_001348193 NP_001348194 NP_001348195 NP_001348196 NP_001348197 NP_001348198 Location (UCSC) Chr 5: 141.96 – 141.99 Mb Chr 18: 38.42 – 38.45 Mb PubMed search [3] [4]
Wikidata
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E3 ubiquitin-protein ligase RNF14 is an enzyme that in humans is encoded by the RNF14 gene.^[5][6][7]

Function

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.^[7] Another function of RNF14 protein relates to its regulation of the inter-relationship between bioenergetic status and inflammation. It influences the expression of mitochondrial and immune-related genes in skeletal muscle including cytokines and interferon regulatory factors.^[8]

Interactions

RNF14 has been shown to interact with the Androgen receptor.^{[5][9][10][11]}

See also

• RING finger domain

References

1. GRCh38: Ensembl release 89: ENSG00000013561 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060450 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kang HY, Yeh S, Fujimoto N, Chang C (Apr 1999). "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor". J Biol Chem. 274 (13): 8570–6. doi:10.1074/jbc.274.13.8570. PMID 10085091.
6. Ueki N, Seki N, Yano K, Masuho Y, Saito T, Muramatsu M (Jun 1999). "Isolation and characterization of a novel human gene (HFB30) which encodes a protein with a RING finger motif". Biochim Biophys Acta. 1445 (2): 232–6. doi:10.1016/s0167-4781(99)00045-7. PMID 10320776.
7. EntrezGene 9604
8. Ingham AB, Osborne SA, Menzies M, Briscoe S, Chen W, Kongsuwan K, et al. (January 2014). "RNF14 is a regulator of mitochondrial and immune function in muscle". BMC Systems Biology. 8: 10. doi:10.1186/1752-0509-8-10. PMC 3906743. PMID 24472305.
9. Miyamoto H, Rahman M, Takatera H, Kang HY, Yeh S, Chang HC, Nishimura K, Fujimoto N, Chang C (Feb 2002). "A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth". J. Biol. Chem. 277 (7): 4609–17. doi:10.1074/jbc.M108312200. PMID 11673464.
10. He B, Minges JT, Lee LW, Wilson EM (Mar 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". J. Biol. Chem. 277 (12): 10226–35. doi:10.1074/jbc.M111975200. PMID 11779876.
11. He B, Wilson EM (Mar 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. 23 (6): 2135–50. doi:10.1128/mcb.23.6.2135-2150.2003. PMC 149467. PMID 12612084.

Further reading

• Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (1999). "Selection system for genes encoding nuclear-targeted proteins". Nat. Biotechnol. 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615. S2CID 20001769.
• Ito K, Adachi S, Iwakami R, Yasuda H, Muto Y, Seki N, Okano Y (2001). "N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8". Eur. J. Biochem. 268 (9): 2725–32. doi:10.1046/j.1432-1327.2001.02169.x. PMID 11322894.
• Miyamoto H, Rahman M, Takatera H, Kang HY, Yeh S, Chang HC, Nishimura K, Fujimoto N, Chang C (2002). "A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth". J. Biol. Chem. 277 (7): 4609–17. doi:10.1074/jbc.M108312200. PMID 11673464.
• Ueda T, Mawji NR, Bruchovsky N, Sadar MD (2002). "Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells". J. Biol. Chem. 277 (41): 38087–94. doi:10.1074/jbc.M203313200. PMID 12163482.
• He B, Wilson EM (2003). "Electrostatic Modulation in Steroid Receptor Recruitment of LXXLL and FXXLF Motifs". Mol. Cell. Biol. 23 (6): 2135–50. doi:10.1128/MCB.23.6.2135-2150.2003. PMC 149467. PMID 12612084.
• Mestayer C, Blanchère M, Jaubert F, Dufour B, Mowszowicz I (2003). "Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines". Prostate. 56 (3): 192–200. doi:10.1002/pros.10229. PMID 12772188. S2CID 23253844.
• Wang L, Hsu CL, Ni J, Wang PH, Yeh S, Keng P, Chang C (2004). "Human Checkpoint Protein hRad9 Functions as a Negative Coregulator To Repress Androgen Receptor Transactivation in Prostate Cancer Cells". Mol. Cell. Biol. 24 (5): 2202–13. doi:10.1128/MCB.24.5.2202-2213.2004. PMC 350564. PMID 14966297.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Lin DY, Fang HI, Ma AH, Huang YS, Pu YS, Jenster G, Kung HJ, Shih HM (2004). "Negative Modulation of Androgen Receptor Transcriptional Activity by Daxx". Mol. Cell. Biol. 24 (24): 10529–41. doi:10.1128/MCB.24.24.10529-10541.2004. PMC 533990. PMID 15572661.
• Yang Z, Chang YJ, Miyamoto H, Ni J, Niu Y, Chen Z, Chen YL, Yao JL, di Sant'Agnese PA, Chang C (2007). "Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth". Mol. Endocrinol. 21 (2): 343–58. doi:10.1210/me.2006-0104. PMID 17082327.
• Yang Z, Chang YJ, Miyamoto H, Yeh S, Yao JL, di Sant'Agnese PA, Tsai MY, Chang C (2007). "Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54". Endocrinology. 148 (3): 1340–9. doi:10.1210/en.2006-0716. PMID 17110431.
• Kikuchi H, Uchida C, Hattori T, Isobe T, Hiramatsu Y, Kitagawa K, Oda T, Konno H, Kitagawa M (2007). "ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells". Carcinogenesis. 28 (8): 1752–8. doi:10.1093/carcin/bgm120. PMID 17510080.

External links

• RNF14 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• NURSA C127

This article incorporates text from the United States National Library of Medicine, which is in the public domain.