CRTC1

CRTC1
Identifiers
Aliases	CRTC1, MECT1, TORC-1, TORC1, WAMTP1, CREB regulated transcription coactivator 1, MAML2, Mam-2
External IDs	OMIM: 607536; MGI: 2142523; HomoloGene: 41607; GeneCards: CRTC1; OMA:CRTC1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 18,683,678 bp[1] End 18,782,333 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.3 Start 70,835,005 bp[2] End 70,892,229 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell paraflocculus of cerebellum right hemisphere of cerebellum Brodmann area 10 middle frontal gyrus frontal pole cerebellar vermis right frontal lobe nucleus accumbens cingulate gyrus Top expressed in superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex genital tubercle lumbar subsegment of spinal cord tail of embryo neural layer of retina cerebellar cortex hippocampus proper zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cAMP response element binding protein binding Cellular component soma plasma membrane dendrite synapse nucleus nucleoplasm cytoplasm cytosol nuclear body postsynaptic density glutamatergic synapse Biological process positive regulation of CREB transcription factor activity viral process positive regulation of dendrite development memory entrainment of circadian clock by photoperiod protein homotetramerization positive regulation of long-term synaptic potentiation transcription, DNA-templated positive regulation of transcription by RNA polymerase II rhythmic process regulation of transcription, DNA-templated energy homeostasis negative regulation of membrane hyperpolarization postsynapse to nucleus signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23373 382056 Ensembl ENSG00000105662 ENSMUSG00000003575 UniProt Q6UUV9 Q68ED7 RefSeq (mRNA) NM_001098482 NM_015321 NM_025021 NM_001004062 RefSeq (protein) NP_001091952 NP_056136 NP_001004062 NP_001391344 NP_001391345 NP_001391346 NP_001391347 NP_001391348 NP_001391349 NP_001391350 NP_001391351 NP_001391352 NP_001391353 NP_001391354 NP_001391355 NP_001391356 NP_001391357 NP_001391358 NP_001391359 Location (UCSC) Chr 19: 18.68 – 18.78 Mb Chr 8: 70.84 – 70.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Not to be confused with mTORC1.

CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1), is a protein that in humans is encoded by the CRTC1 gene.^[5][6][7][8] It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands^[9] and various regions of the adult central nervous system.^[10]

Clinical significance

Production of CRTC1 is blocked in Alzheimer's disease.^[11]

See also

• Transcription coregulator

References

1. GRCh38: Ensembl release 89: ENSG00000105662 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003575 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ (Feb 2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nature Genetics. 33 (2): 208–13. doi:10.1038/ng1083. PMID 12539049. S2CID 23417795.
6. Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Aug 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
7. Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
8. "Entrez Gene: CRTC1 CREB regulated transcription coactivator 1".
9. Huret J-L. "CRTC1 (CREB regulated transcription coactivator 1)". Atlas of Genetics and Cytogenetics in Oncology and Haematology. INSERM U 935, Genetics, Dept Medical Information, University Hospital of Poitiers.
10. Kovács KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR (Mar 2007). "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity". Proceedings of the National Academy of Sciences of the United States of America. 104 (11): 4700–5. Bibcode:2007PNAS..104.4700K. doi:10.1073/pnas.0607524104. PMC 1838663. PMID 17360587.
11. Parra-Damas A, Valero J, Chen M, España J, Martín E, Ferrer I, Rodríguez-Alvarez J, Saura CA (Apr 2014). "Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages". The Journal of Neuroscience. 34 (17): 5776–87. doi:10.1523/JNEUROSCI.5288-13.2014. PMC 6608295. PMID 24760838.

Further reading

• Kovács KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR (Mar 2007). "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity". Proceedings of the National Academy of Sciences of the United States of America. 104 (11): 4700–5. Bibcode:2007PNAS..104.4700K. doi:10.1073/pnas.0607524104. PMC 1838663. PMID 17360587.
• Takemori H, Kajimura J, Okamoto M (Jul 2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain". The FEBS Journal. 274 (13): 3202–9. doi:10.1111/j.1742-4658.2007.05889.x. PMID 17565599. S2CID 30323449.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
• Enlund F, Behboudi A, Andrén Y, Oberg C, Lendahl U, Mark J, Stenman G (Jan 2004). "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors". Experimental Cell Research. 292 (1): 21–8. doi:10.1016/j.yexcr.2003.09.007. PMID 14720503.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" (PDF). Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081. S2CID 18616459.
• Bittinger MA, McWhinnie E, Meltzer J, Iourgenko V, Latario B, Liu X, Chen CH, Song C, Garza D, Labow M (Dec 2004). "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins". Current Biology. 14 (23): 2156–61. Bibcode:2004CBio...14.2156B. doi:10.1016/j.cub.2004.11.002. PMID 15589160. S2CID 5934014.
• Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G (Jun 2005). "Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion". Genes, Chromosomes & Cancer. 43 (2): 202–5. doi:10.1002/gcc.20168. PMID 15729701. S2CID 39267344.
• Komiya T, Park Y, Modi S, Coxon AB, Oh H, Kaye FJ (Oct 2006). "Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation". Oncogene. 25 (45): 6128–32. doi:10.1038/sj.onc.1209627. PMID 16652146. S2CID 22409834.
• Siu YT, Chin KT, Siu KL, Yee Wai Choy E, Jeang KT, Jin DY (Jul 2006). "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats". Journal of Virology. 80 (14): 7052–9. doi:10.1128/JVI.00103-06. PMC 1489057. PMID 16809310.
• Katoh Y, Takemori H, Lin XZ, Tamura M, Muraoka M, Satoh T, Tsuchiya Y, Min L, Doi J, Miyauchi A, Witters LA, Nakamura H, Okamoto M (Jun 2006). "Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade". The FEBS Journal. 273 (12): 2730–48. doi:10.1111/j.1742-4658.2006.05291.x. PMID 16817901. S2CID 44953050.
• Okabe M, Miyabe S, Nagatsuka H, Terada A, Hanai N, Yokoi M, Shimozato K, Eimoto T, Nakamura S, Nagai N, Hasegawa Y, Inagaki H (Jul 2006). "MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma". Clinical Cancer Research. 12 (13): 3902–7. doi:10.1158/1078-0432.CCR-05-2376. PMID 16818685. S2CID 17202179.

External links

• CRTC1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CRTC1 genome location and CRTC1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.