The first scientific expedition to the site was carried out in 1908 by Harry Swarth and Joseph Grinnell on behalf of University of California, Berkeley's Museum of Vertebrate Zoology.[14] Philip L. Boyd, a Regent of the University of California, leased the land for the Living Desert Zoo and Gardens and invited faculty of the newly opened University of California, Riverside to use the property for research. When the need for a non-public range became evident, Boyd donated the initial 1,701 acres (6.88 km2) of land in Deep Canyon in 1958 as well as the funding to spur the University to acquire other contiguous properties. Construction began on the first hard facilities on site in 1961 and commemoration of the site with a bronze plaque took place on March 7, 1970 naming the center after Boyd.[14] The first director of the research center was Irwin P. Ting.[15] As of 2015 the director of the research center is Dr. Chris Tracy.[16]
The cactus Opuntia acanthocarpa has been studied at Agave Hill.[17] In 2010 a study of 35 species of Mutillid wasps revealed four new species, two of which (Odontophotopsis hammetti and Sphaeropthalma mankelli) are only known to exist at the center.[18] The center was the study ground for a 2013 National Science Foundation grant to develop a new method for identifying species of nematodes.[19] A series of five books (Mammals of Deep Canyon in 1968, Ants of Deep Canyon in 1973, Deep Canyon, a Desert Wilderness for Science in 1976, Birds of Deep Canyon in 1979, and Birds of Southern California's Deep Canyon in 1983) discuss the biodiversity of the area.[20]
^The University of California has agreements with federal agencies for the use of tens of thousands of acres adjacent to the Research Center. Studies at Deep Canyon often cover transects across the adjacent properties.[3]