Pheneturide

Pheneturide

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	N03AX13 (WHO)
Identifiers
IUPAC name (RS)-N-Carbamoyl-2-phenyl-butanamide
CAS Number	90-49-3^N
PubChem CID	72060
ChemSpider	65046^Y
UNII	878CEJ4HGX
KEGG	D01190^Y
CompTox Dashboard (EPA)	DTXSID4020612
ECHA InfoCard	100.001.817
Chemical and physical data
Formula	C11H14N2O2
Molar mass	206.245 g·mol^−1
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
SMILES O=C(N)NC(=O)C(c1ccccc1)CC
InChI InChI=1S/C11H14N2O2/c1-2-9(10(14)13-11(12)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H3,12,13,14,15)^Y Key:AJOQSQHYDOFIOX-UHFFFAOYSA-N^Y
^NY (what is this?)  (verify)

Pheneturide (INN, BAN) (brand names Benuride, Deturid, Pheneturid, Septotence, Trinuride),^[1] also known as phenylethylacetylurea (or ethylphenacemide), is an anticonvulsant of the ureide class.^[2][3] Conceptually, it can be formed in the body as a metabolic degradation product from phenobarbital. It is considered to be obsolete^[4] and is now seldom used.^[5] It is marketed in Europe, including in Poland, Spain and the United Kingdom.^[6] Pheneturide has a similar profile of anticonvulsant activity and toxicity relative to phenacemide.^[7][8] As such, it is only used in cases of severe epilepsy when other, less-toxic drugs have failed.^[8] Pheneturide inhibits the metabolism and thus increases the levels of other anticonvulsants, such as phenytoin.^[5][6]

See also

• Phenacemide

References

1. Muller (19 June 1998). European Drug Index: European Drug Registrations, Fourth Edition. CRC Press. pp. 998–. ISBN 978-3-7692-2114-5.
2. Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 959–. ISBN 978-1-4757-2085-3.
3. Byrne B, Rothchild R (1999). "1H NMR studies of drugs with achiral and chiral lanthanide shift reagents: applications to the anticonvulsant pheneturide". Chirality. 11 (7): 529–35. doi:10.1002/(SICI)1520-636X(1999)11:7<529::AID-CHIR3>3.0.CO;2-K. PMID 10423278.
4. Levy RH (2002). Antiepileptic Drugs. Lippincott Williams & Wilkins. pp. 210–. ISBN 978-0-7817-2321-3.
5. Denham MJ (6 December 2012). The Treatment of Medical Problems in the Elderly. Springer Science & Business Media. pp. 335–. ISBN 978-94-011-6223-4.
6. Vida J (19 July 2013). Anticonvulsants. Elsevier. pp. 4, 42. ISBN 978-0-323-14395-0.
7. deStevens G, Zingel V, Leschke C, Hoeprich PD, Schultz RM, Mehrotra PK, Batra S, Bhaduri AP, Saxena AK, Saxena M, eds. (11 November 2013). Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques. Basel: Birkhäuser. pp. 217–. ISBN 978-3-0348-7161-7. Retrieved 3 September 2016.
8. Lancaster R (22 October 2013). Pharmacology in Clinical Practice. Elsevier. pp. 222–. ISBN 978-1-4831-9294-9.