Palsana has a hot semi-arid climate (Köppen climate classificationBSh) climate, rains occur in the monsoon months between June and September. Temperatures remain relatively high throughout the year, with the summer months of April to July having average daily temperatures of around 30 °C (86 °F). The maximum temperatures during the months of May and June can reach close to 50 °C (122 °F) with little to no humidity. During the monsoon there are frequent, heavy rains and thunderstorms, but flooding is not common. The winter months of November to February are mild and pleasant, with average temperatures ranging from 15–18 °C (59–64 °F) and with little or no humidity. There are however occasional cold fronts that lead to temperatures near freezing.
Palsana is well connected by roads from all the major cities of Rajasthan. One national highway NH-52 passes through center of city. NH-52 connects Sikar to Jaipur, Kaithal and Bikaner. The western freight corridor will also connect with Sikar. Kotputali Kuchaman Megahighway also passes through Palsana.