PTPRH

PTPRH
Identifiers
Aliases	PTPRH, R-PTP-H, SAP1, protein tyrosine phosphatase, receptor type H, protein tyrosine phosphatase receptor type H
External IDs	OMIM: 602510; MGI: 3026877; HomoloGene: 37693; GeneCards: PTPRH; OMA:PTPRH - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 55,181,247 bp[1] End 55,209,506 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 4,551,611 bp[2] End 4,607,040 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa duodenum pancreatic ductal cell mucosa of transverse colon gallbladder mucosa of ileum rectum islet of Langerhans oocyte spleen Top expressed in jejunum ileum colon duodenum stomach striatum of neuraxis superior frontal gyrus cerebellar cortex primary visual cortex Hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity phosphatase activity transmembrane receptor protein tyrosine phosphatase activity protein binding phosphoprotein phosphatase activity hydrolase activity Cellular component cytoplasm integral component of membrane integral component of plasma membrane membrane plasma membrane microvillus apical plasma membrane microvillus membrane cell projection Biological process protein dephosphorylation dephosphorylation apoptotic process peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5794 545902 Ensembl ENSG00000080031 ENSMUSG00000035429 UniProt Q9HD43 E9Q0N2 RefSeq (mRNA) NM_001161440 NM_002842 NM_207270 RefSeq (protein) NP_001154912 NP_002833 NP_997153 Location (UCSC) Chr 19: 55.18 – 55.21 Mb Chr 7: 4.55 – 4.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH gene.^[5][6]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000080031 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035429 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Matozaki T, Suzuki T, Uchida T, Inazawa J, Ariyama T, Matsuda K, Horita K, Noguchi H, Mizuno H, Sakamoto C, et al. (Feb 1994). "Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers". J Biol Chem. 269 (3): 2075–81. doi:10.1016/S0021-9258(17)42137-5. PMID 8294459.
6. "Entrez Gene: PTPRH protein tyrosine phosphatase, receptor type, H".

Further reading

• Noguchi T, Tsuda M, Takeda H, et al. (2001). "Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas". J. Biol. Chem. 276 (18): 15216–24. doi:10.1074/jbc.M007208200. PMID 11278335.
• Marneros AG, Mehenni H, Reichenberger E, et al. (2001). "Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome". Cytogenet. Cell Genet. 92 (3–4): 213–6. doi:10.1159/000056905. PMID 11435690. S2CID 20187527.
• Takada T, Noguchi T, Inagaki K, et al. (2002). "Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1". J. Biol. Chem. 277 (37): 34359–66. doi:10.1074/jbc.M206541200. PMID 12101188.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagano H, Noguchi T, Inagaki K, et al. (2003). "Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma". Oncogene. 22 (30): 4656–63. doi:10.1038/sj.onc.1206588. PMID 12879010. S2CID 2707273.
• Pasquali C, Curchod ML, Wälchli S, et al. (2004). "Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor". Mol. Endocrinol. 17 (11): 2228–39. doi:10.1210/me.2003-0011. PMID 12907755.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.