Mulipola is from the village of Siutu and was active in bringing gender-equality to her village council.[4] She previously worked as an auditor[5] and deputy country manager[1] for Western Union. She was first elected to the Legislative Assembly of Samoa in the 2021 Samoan general election.[5][6] On 24 May 2021 she was appointed Minister of Finance in the elected cabinet of Fiamē Naomi Mataʻafa.[7] The appointment was disputed by the caretaker government. On 23 July 2021 the Court of Appeal ruled that the swearing-in ceremony was constitutional and binding, and that FAST had been the government since 24 May.[8]
In August 2021 in response to opposition claims that she had sought advice from New Zealand on an upcoming budget, Mulipola suggested that she lacked confidence in Ministry of Finance chief executive Leasiosiofa’asisina Oscar Malielegaoi, opposition leader Tuila'epa Sa'ilele Malielegaoi's son, as his family connection to the opposition created a perceived conflict of interest.[9] On 27 August Mulipola called reports that Malielegaoi had been fired "misinformation".[10] The next day Malielegaoi resigned, saying that the Minister had demanded his resignation.[11] On 28 August Mulipola issued a statement saying that Malielegaoi's conflict of interest was not sustainable and that she had "reluctantly decided to accept his resignation".[12]
In a cabinet reshuffle on 6 September 2023 she was replaced as Minister of Finance by Lautimuia Uelese Vaʻai. Mulipola was instead appointed Minister of Women, Community and Social Development, replacing Leota Laki Lamositele from 1 October 2023.[13]