Molybdopterin synthase sulfurtransferase

Molybdopterin synthase sulfurtransferase
Identifiers
EC no.	2.8.1.11
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Molybdopterin synthase sulfurtransferase (EC 2.8.1.11, adenylyltransferase and sulfurtransferase MOCS3, Cnx5 (gene), molybdopterin synthase sulfurylase) is an enzyme with systematic name persulfurated L-cysteine desulfurase:(molybdopterin-synthase sulfur-carrier protein)-Gly-Gly sulfurtransferase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

[molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine ${\displaystyle \rightleftharpoons }$ AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + cysteine desulfurase

The enzyme transfers sulfur to form a thiocarboxylate moiety on the C-terminal glycine of the small subunit of molybdopterin synthase.

References

1. Matthies A, Nimtz M, Leimkühler S (May 2005). "Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry". Biochemistry. 44 (21): 7912–20. doi:10.1021/bi0503448. PMID 15910006.
2. Leimkühler S, Rajagopalan KV (June 2001). "A sulfurtransferase is required in the transfer of cysteine sulfur in the in vitro synthesis of molybdopterin from precursor Z in Escherichia coli". The Journal of Biological Chemistry. 276 (25): 22024–31. doi:10.1074/jbc.M102072200. PMID 11290749.
3. Hänzelmann P, Dahl JU, Kuper J, Urban A, Müller-Theissen U, Leimkühler S, Schindelin H (December 2009). "Crystal structure of YnjE from Escherichia coli, a sulfurtransferase with three rhodanese domains". Protein Science. 18 (12): 2480–91. doi:10.1002/pro.260. PMC 2821267. PMID 19798741.
4. Dahl JU, Urban A, Bolte A, Sriyabhaya P, Donahue JL, Nimtz M, Larson TJ, Leimkühler S (October 2011). "The identification of a novel protein involved in molybdenum cofactor biosynthesis in Escherichia coli". The Journal of Biological Chemistry. 286 (41): 35801–12. doi:10.1074/jbc.M111.282368. PMC 3195606. PMID 21856748.

External links

• Molybdopterin+synthase+sulfurtransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)