Mathira was born into a Muslim family in Harare, Zimbabwe to a South African father and a Pakistani mother.[4] Her sister Rose Muhammad is also an actress. She was educated in Zimbabwe before moving to Pakistan with her family amid unrest in Zimbabwe.[4] She made her debut in music videos of Jadugar, Desi Beat and "Nachdi Kamal" by Malkoo and Woh Kaun Thi by Rizwan-ul-Haq, and "Jotha Tu Hai" by Arbaz Khan. In March 2011, she got a chance to host a late-night programmeLove Indicator on Vibe TV.
Mathira then shot for the cover of a leading Pakistani fashion magazine.[5] In 2011, she also hosted an AAG TV's show Baji Online. In 2013, she made her debut in Bollywood by doing an item song "Lakk Ch Current" in Indian Punjabi film Young Malang.[6] She has also done an item number "Masti Mein Doobi Raat Hai" in the film Main Hoon Shahid Afridi starring Humayun Saeed.[7] She then appeared in the music video of the song "Jhootha" with young rapper Arbaz Khan, which was released on 30 December 2013.
Mathira married Punjabi singer Farran J Mirza (also known as Flint J) in 2012. The couple has a son, Aahil Rizvi who was born in September 2014.[13] The couple separated in January 2018.[14]