Villegas was called up to the Major Leagues in July 2000 after Mike Remlinger suffered an injury and Don Wengert was designated for assignment.[3] He made his Major League debut on July 3, 2000 at Turner Field in relief of Terry Mulholland. He would face 15 batters and get eight outs, allowing four earned runs to score. He twice faced future Hall of FamerVlad Guerrero, first hitting him with a pitch and then getting him to ground out.[4] A few days later he would be replaced on the roster by pitcher Scott Kamieniecki and would not pitch in the Major Leagues again.[5]
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