When it comes to ileitis, the majority of cases are caused by an acute, self-limited form of lower right quadrant pain and/or diarrhea. However, other conditions, such as M. tuberculosis or vasculitis, can cause chronic, debilitating symptoms that are complicated by hemorrhage, obstructive symptoms, and/or extraintestinal manifestations. Unless symptoms indicate that additional testing is necessary, ileitis linked to spondyloarthropathy or nonsteroidal anti-inflammatory drugs is usually subclinical and goes unnoticed.[2]