GLUT5

SLC2A5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YB9, 4YBQ
Identifiers
Aliases	SLC2A5, GLUT-5, GLUT5, solute carrier family 2 member 5
External IDs	OMIM: 138230; MGI: 1928369; HomoloGene: 74459; GeneCards: SLC2A5; OMA:SLC2A5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.23 Start 9,035,106 bp[1] End 9,088,478 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 150,203,740 bp[2] End 150,228,626 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa duodenum biceps brachii Skeletal muscle tissue of biceps brachii vastus lateralis muscle muscle of thigh left testis triceps brachii muscle right testis bone marrow Top expressed in seminiferous tubule spermatid spermatocyte islet of Langerhans right kidney duodenum proximal tubule parotid gland human kidney jejunum More reference expression data BioGPS n/a
Gene ontology Molecular function transmembrane transporter activity transporter activity fructose binding fructose transmembrane transporter activity glucose transmembrane transporter activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane apical plasma membrane sarcolemma extracellular exosome specific granule membrane Biological process cellular response to fructose stimulus fructose transmembrane transport carbohydrate transport fructose import across plasma membrane response to fructose transmembrane transport glucose transmembrane transport regulation of systemic arterial blood pressure mediated by a chemical signal neutrophil degranulation intestinal hexose absorption transport carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6518 56485 Ensembl ENSG00000142583 ENSMUSG00000028976 UniProt P22732 Q9WV38 RefSeq (mRNA) NM_001135585 NM_003039 NM_001328619 NM_001328620 NM_001328621 NM_019741 RefSeq (protein) NP_001129057 NP_001315548 NP_001315549 NP_001315550 NP_003030 NP_062715 Location (UCSC) Chr 1: 9.04 – 9.09 Mb Chr 4: 150.2 – 150.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GLUT5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine.^[5] GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen. GLUT5 is also expressed in skeletal muscle,^[6] testis, kidney, fat tissue (adipocytes), and brain.^[7]

Fructose malabsorption or Dietary Fructose Intolerance is a dietary disability of the small intestine, where the amount of fructose carrier in enterocytes is deficient.^[8]

In humans the GLUT5 protein is encoded by the SLC2A5 gene.^[9]

Regulation

Fructose uptake rate by GLUT5 is significantly reduced by diabetes mellitus, hypertension, obesity, fructose malabsorption, and inflammation. However, age-related changes in fructose intake capability are not explained by the rate of expression of GLUT5.^[10][11][12] The absorption of fructose in the simultaneous presence of glucose is improved, while sorbitol is inhibitory.^[13] Fructose absorption by GLUT5 can be investigated using intestinal organoids.^[14][15]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

1. The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

References

1. GRCh38: Ensembl release 89: ENSG00000142583 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028976 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Uldry M, Thorens B (February 2004). "The SLC2 family of facilitated hexose and polyol transporters" (PDF). Pflügers Archiv: European Journal of Physiology. 447 (5): 480–9. doi:10.1007/s00424-003-1085-0. PMID 12750891. S2CID 25539725.
6. Hundal HS, Darakhshan F, Kristiansen S, Blakemore SJ, Richter EA (1998). "GLUT5 Expression and Fructose Transport in Human Skeletal Muscle". Skeletal Muscle Metabolism in Exercise and Diabetes. Advances in Experimental Medicine and Biology. Vol. 441. pp. 35–45. doi:10.1007/978-1-4899-1928-1_4. ISBN 978-1-4899-1930-4. PMID 9781312.
7. Douard V, Ferraris RP (August 2008). "Regulation of the fructose transporter GLUT5 in health and disease". American Journal of Physiology. Endocrinology and Metabolism. 295 (2): E227–37. doi:10.1152/ajpendo.90245.2008. PMC 2652499. PMID 18398011.
8. Barone S, Fussell SL, Singh AK, Lucas F, Xu J, Kim C, et al. (February 2009). "Slc2a5 (Glut5) Is Essential for the Absorption of Fructose in the Intestine and Generation of Fructose-induced Hypertension". The Journal of Biological Chemistry. 284 (8): 5056–66. doi:10.1074/jbc.M808128200. PMC 2643499. PMID 19091748.
9. White PS, Jensen SJ, Rajalingam V, Stairs D, Sulman EP, Maris JM, et al. (1998). "Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2". Cytogenetics and Cell Genetics. 81 (1): 60–4. doi:10.1159/000014989. PMID 9691177. S2CID 46770845.
10. Douard V, Ferraris RP (August 2008). "Regulation of the fructose transporter GLUT5 in health and disease". Am. J. Physiol. Endocrinol. Metab. 295 (2): E227–37. doi:10.1152/ajpendo.90245.2008. PMC 2652499. PMID 18398011.
11. Litherland GJ, Hajduch E, Gould GW, Hundal HS (June 2004). "Fructose transport and metabolism in adipose tissue of Zucker rats: diminished GLUT5 activity during obesity and insulin resistance" (PDF). Mol. Cell. Biochem. 261 (1–2): 23–33. doi:10.1023/b:mcbi.0000028734.77867.d2. PMID 15362482. S2CID 13029991. Archived from the original (PDF) on September 9, 2012.
12. Drozdowski LA, Woudstra TD, Wild GE, Clandinin MT, Thomson AB (October 2004). "Age-associated changes in intestinal fructose uptake are not explained by alterations in the abundance of GLUT5 or GLUT2". J. Nutr. Biochem. 15 (10): 630–7. doi:10.1016/j.jnutbio.2004.06.003. PMID 15542355.
13. Heinrich Kasper: Ernährungsmedizin und Diätetik. 11. Auflage, Elsevier, Urban&Fischer-Verlag, 2009, ISBN 9783437420122, S. 208
14. Zietek T, Giesbertz P, Ewers M, Reichart F, Weinmüller M, Demir IE, et al. (2020). "Organoids to Study Intestinal Nutrient Transport, Drug Uptake and Metabolism – Update to the Human Model and Expansion of Applications". Frontiers in Bioengineering and Biotechnology. 8: 577656. doi:10.3389/fbioe.2020.577656. ISSN 2296-4185. PMC 7516017. PMID 33015026.
15. Zietek T, Rath E, Haller D, Daniel H (November 2015). "Intestinal organoids for assessing nutrient transport, sensing and incretin secretion". Scientific Reports. 5 (1): 16831. Bibcode:2015NatSR...516831Z. doi:10.1038/srep16831. PMC 4652176. PMID 26582215.

External links

• GLUT5+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)