SLC22A14

SLC22A14
Identifiers
Aliases	SLC22A14, OCTL2, OCTL4, ORCTL4, solute carrier family 22 member 14
External IDs	OMIM: 604048; MGI: 2685974; HomoloGene: 3530; GeneCards: SLC22A14; OMA:SLC22A14 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.2 Start 38,282,294 bp[1] End 38,318,575 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F3 Start 118,998,523 bp[2] End 119,194,619 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle pancreatic ductal cell lateral nuclear group of thalamus left testis right testis tibialis anterior muscle pars reticulata male germ cell deltoid muscle sperm Top expressed in spermatid seminiferous tubule spermatocyte proximal tubule yolk sac white adipose tissue spleen islet of Langerhans human kidney right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function organic cation transmembrane transporter activity transmembrane transporter activity inorganic anion exchanger activity sodium-independent organic anion transmembrane transporter activity Cellular component integral component of membrane integral component of plasma membrane membrane Biological process organic cation transport transmembrane transport inorganic anion transport sodium-independent organic anion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9389 382113 Ensembl ENSG00000144671 ENSMUSG00000070280 UniProt Q9Y267 Q497L9 RefSeq (mRNA) NM_004803 NM_001320033 NM_001037749 RefSeq (protein) NP_001306962 NP_004794 NP_001032838 Location (UCSC) Chr 3: 38.28 – 38.32 Mb Chr 9: 119 – 119.19 Mb PubMed search [3] [4]
Wikidata
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Solute carrier family 22 member 14 is a protein that in humans is encoded by the SLC22A14 gene.^[5]

Function

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 3. The encoded protein is a transmembrane protein which is thought to transport small molecules and since this protein is conserved among several species, it is suggested to have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].

References

1. GRCh38: Ensembl release 89: ENSG00000144671 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070280 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Solute carrier family 22 member 14". Retrieved 2020-01-19.

Further reading

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.