In 2007, Guillermo del Toro said that a project which he "would kill to make" would be a faithful "Miltonian tragedy" version of Frankenstein, citing Frank Darabont's "pretty much perfect" script, which evolved into Kenneth Branagh's Frankenstein.[1] In January 2008, he revealed that he was then in the process of crafting drawings which he hoped to use as a basis for the world of the film, and that, additionally, he had begun taking script notes but stopped once the WGA strike had occurred.[2] The following month, del Toro said of his vision:
"What I'm trying to do is take the myth and do something with it, but combining elements of Frankenstein and Bride of Frankenstein without making it just a classical myth of the monster. The best moments in my mind of Frankenstein, of the novel, are yet to be filmed [...] The only guy that has ever nailed for me the emptiness, not the tragic, not the Miltonian dimension of the monster, but the emptiness is Christopher Lee in the Hammer films, where he really looks like something obscenely alive. Boris Karloff has the tragedy element nailed down but there are so many versions, including that great screenplay by Frank Darabont that was ultimately not really filmed".[3]
Later that year, in September, the film was set up through del Toro's three-year first-look picture deal at Universal Pictures, alongside a slate of films he was announced to direct including Dr. Jekyll and Mr. Hyde, Slaughterhouse-Five and Drood.[4] Del Toro cited Bernie Wrightson's Frankenstein illustrations as inspiration, and said the film would not be a direct adaptation of Mary Shelley's novel, but rather "an adventure story that involves the creature."[5][6] Del Toro wanted Wrightson to design his version of the creature.[7]
In 2009, del Toro stated that production on Frankenstein was not likely to begin for at least four years.[8] Despite this, he had already cast frequent collaborator Doug Jones in the role of Frankenstein's monster and begun initiating makeup tests with the actor.[9][10] Jones later commented that the project was shelved due to Universal's future plans for their Dark Universe franchise.[11] In 2013, del Toro expressed interest in casting Benedict Cumberbatch for the role of the monster.[12] In 2014, del Toro said that he would like to do versions of both Frankenstein and Bride of Frankenstein, and that Universal chairperson Donna Langley had approached him several times about getting it going but that he was reluctant to do so because it is his "dream project".[13] In 2020, in an interview promoting the film Antlers, del Toro stated that if he had the funding, he would make an adaptation of Frankenstein that would span two to three films due to the book's complexity and changing points of view.[14]