In 1954, Chen worked at the Princeton Plasma Physics Laboratory (PPPL), where he worked initially with the Model B1 Stellarator, a device used to confine hot plasma with magnetic fields in order to sustain a controlled nuclear fusion reaction. With the B1 Stellarator, Chen was the first to show that electrons could be trapped by a magnetic field for millions of traverses.[1] Chen remained at PPPL until 1969.
Chen has been concerned with not only basic research in plasma physics and magnetic and inertial confinement fusion, but also with low-energy plasma physics for industrial applications such as semiconductors. He has worked in both theoretical and experimental plasma physics. He has studied multiple subfields of plasma physics including: plasma diagnostics, accelerator concepts with plasmas, helicon plasma sources, plasma instabilities of laser interaction, Langmuir probes, resistive drift waves, anomalous diffusion, and Q-machines. He wrote a very well known and highly regarded Introductory plasma physics textbook (see below).