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Fenproporex
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	By mouth
ATC code	none;
Legal status
Legal status	BR: Class B2 (Anorectic drugs); CA: Schedule IV; DE: Prescription only (Anlage III for higher doses); US: Schedule IV;
Pharmacokinetic data
Metabolism	partly converted to amphetamine (30 to 60%)
Excretion	urine, mainly as amphetamine, about 5 to 9% unchanged
Identifiers
	IUPAC name 3-(1-phenylpropan-2-ylamino)propanenitrile;
CAS Number	16397-28-7 ;
PubChem CID	61810;
DrugBank	DB01550 ;
ChemSpider	55690 ;
UNII	W0194S5FOA;
KEGG	D07947 ;
ChEMBL	ChEMBL2105566 ;
CompTox Dashboard (EPA)	DTXSID0043921 ;
ECHA InfoCard	100.036.752
Chemical and physical data
Formula	C12H16N2
Molar mass	188.274 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N#CCCNC(Cc1ccccc1)C;
	InChI InChI=1S/C12H16N2/c1-11(14-9-5-8-13)10-12-6-3-2-4-7-12/h2-4,6-7,11,14H,5,9-10H2,1H3 ; Key:IQUFSXIQAFPIMR-UHFFFAOYSA-N ;
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Fenproporex (Perphoxene) (N-2-Cyanoethylamphetamine) (3-(1-phenylpropan-2-ylamino)propanenitrile) (3-[(1-Methyl-2-Phenylethyl)amino]propiononitrile) is a stimulant drug of the phenethylamine and amphetamine chemical classes that was developed in the 1960s. It is used as an appetite suppressant for the treatment of obesity.^[3]

Fenproporex produces amphetamine as a metabolite^[4]^[5] and was withdrawn in many countries following problems with abuse,^[6] but it is still prescribed in some countries. It is sometimes combined with benzodiazepines, antidepressants, and other compounds to create a version of the "rainbow diet pill".^[7]^[8]^[9]

Fenproporex has never been approved by the US Food and Drug Administration (FDA) for sale in the US due to lack of efficacy and safety data. However, in March 2009, the FDA warned consumers that it has been detected as an unlabeled component of diet pills available over the Internet.^[10] Fenproporex is designated a Schedule IV controlled substance in the US pursuant to the Controlled Substances Act.^[11]

Fenproporex is on the list of substances banned by the World Anti-Doping Agency, and any sportsperson testing positive for the substance faces a ban from competition.^[12]

References

^ ^a ^b ^c Seyffart G (1991). Drug dosage in renal insufficiency. Springer. pp. 245–246. ISBN 978-0-7923-0964-2.
^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ Warembourg H, Jaillard J. Clinical experimentation with fenproporex in the treatment of obesity. Apropos of 40 cases. (French). Journal de la Faculte de médecine et de pharmacie de l'Universite de Lille. 1968 Mar;13(3):Suppl:273-6.
^ Tognoni G, Morselli PL, Garattini S (October 1972). "Amphetamine concentrations in rat brain and human urine after fenproporex administration". European Journal of Pharmacology. 20 (1): 125–6. doi:10.1016/0014-2999(72)90227-0. PMID 4637940.
^ Cody JD (December 1993). "Metabolic Precursors to Amphetamine and Methamphetamine". Forensic Science Review. 5 (2): 109–27. PMID 26270078.
^ Pélissier-Alicot AL, Piercecchi-Marti MD, Bartoli C, Kuhlmann E, Coiffait PE, Sanvoisin A, et al. (March 2006). "Abusive prescription of psychostimulants: a study of two cases". Journal of Forensic Sciences. 51 (2): 407–10. doi:10.1111/j.1556-4029.2006.00078.x. PMID 16566781. S2CID 39460850.
^ Cohen PA (March 2009). "Imported fenproporex-based diet pills from Brazil: a report of two cases". Journal of General Internal Medicine. 24 (3): 430–3. doi:10.1007/s11606-008-0878-4. PMC 2642570. PMID 19096898.
^ Cohen PA, McCormick D, Casey C, Dawson GF, Hacker KA (June 2009). "Imported compounded diet pill use among Brazilian women immigrants in the United States". Journal of Immigrant and Minority Health. 11 (3): 229–36. doi:10.1007/s10903-007-9099-x. PMID 18066718. S2CID 8730835.
^ Cohen PA, Goday A, Swann JP (September 2012). "The return of rainbow diet pills". American Journal of Public Health. 102 (9): 1676–86. doi:10.2105/AJPH.2012.300655. PMC 3482033. PMID 22813089.
^ "Consumer Directed Questions and Answers about FDA's Initiative Against Contaminated Weight Loss Products". FDA/Center for Drug Evaluation and Research. Archived from the original on 17 March 2009.
^ "21 CFR 1308.14(e)(4)". U.S. Government Printing Office. Archived from the original on 2011-10-16. Retrieved 2011-04-20.
^ The 2009 Prohibited List International Standard Archived February 3, 2009, at the Wayback Machine. World Anti-Doping Agency (2009). Retrieved on 2009-08-18.