PROFILBARU.COM

Fenbufen
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	M01AE05 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only);
Identifiers
	IUPAC name 4-(4-Biphenylyl)-4-oxobutanoic acid; or; 4-Oxo-4-(4-phenylphenyl)butanoic acid;
CAS Number	36330-85-5 ;
PubChem CID	3335;
DrugBank	DB08981 ;
ChemSpider	3218 ;
UNII	9815R1WR9B;
KEGG	D01344 ;
ChEBI	CHEBI:31599 ;
ChEMBL	ChEMBL277522 ;
CompTox Dashboard (EPA)	DTXSID9023043 ;
ECHA InfoCard	100.048.148
Chemical and physical data
Formula	C16H14O3
Molar mass	254.285 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	186 °C (367 °F)
	SMILES O=C(O)CCC(=O)c2ccc(c1ccccc1)cc2;
	InChI InChI=1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19) ; Key:ZPAKPRAICRBAOD-UHFFFAOYSA-N ;
	(what is this?) (verify)

Fenbufen is a nonsteroidal anti-inflammatory drug used to treat pain.^[1]

Fenbufen is a member of the propionic acid derivatives class of drugs.^[2]

It was introduced by American Cyanamid under the trade name Lederfen in the 1980s. Due to liver toxicity, it was withdrawn from markets in the developed world in 2010.^[3]^[4]^{: 370, 383–384}

As of 2015 it was available in Taiwan and Thailand under several brand names.^[5]

Preparation

Fenbufen can be synthesized by acylation of biphenyl with succinic anhydride under Friedel-Crafts conditions.^[6]

References

^ Moore RA, Derry S, McQuay HJ (October 2009). "Single dose oral fenbufen for acute postoperative pain in adults". The Cochrane Database of Systematic Reviews. 2009 (4): CD007547. doi:10.1002/14651858.CD007547.pub2. PMC 4175557. PMID 19821427.
^ Brogden RN (1986). "Non-steroidal anti-inflammatory analgesics other than salicylates". Drugs. 32 (Suppl 4): 27–45. doi:10.2165/00003495-198600324-00004. PMID 3552584. S2CID 25471102.
^ "Deleted products 2010". Monthly Index of Medical Specialities (MIMS). Haymarket Media Group Ltd.
^ Lewis JH, Stine JG (2013). "Nonsteroidal Antiinflammatory Drugs and Leukotriene Receptor Antagonists. Chapter 22". In Kaplowitz N, DeLeve LD (eds.). Drug-Induced Liver Disease (3rd ed.). Academic Press. ISBN 978-0-12-387818-2.
^ "International listings for fenbufen". Drugs.com. Retrieved 25 June 2015.
^ Castillo R, Suárez-Herrera M, Aparicio M, Hernández-Lui F, Hernández A (October 1995). "An Improved Synthesis of Fenbulen". Organic Preparations and Procedures International. 27 (5): 550–552. doi:10.1080/00304949509458497.

This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it.

[1] Moore RA, Derry S, McQuay HJ (October 2009). "Single dose oral fenbufen for acute postoperative pain in adults". The Cochrane Database of Systematic Reviews. 2009 (4): CD007547. doi:10.1002/14651858.CD007547.pub2. PMC 4175557. PMID 19821427.

[pmid3552584-2] Brogden RN (1986). "Non-steroidal anti-inflammatory analgesics other than salicylates". Drugs. 32 (Suppl 4): 27–45. doi:10.2165/00003495-198600324-00004. PMID 3552584. S2CID 25471102.

[3] "Deleted products 2010". Monthly Index of Medical Specialities (MIMS). Haymarket Media Group Ltd.

[4] Lewis JH, Stine JG (2013). "Nonsteroidal Antiinflammatory Drugs and Leukotriene Receptor Antagonists. Chapter 22". In Kaplowitz N, DeLeve LD (eds.). Drug-Induced Liver Disease (3rd ed.). Academic Press. ISBN 978-0-12-387818-2.

[5] "International listings for fenbufen". Drugs.com. Retrieved 25 June 2015.

[6] Castillo R, Suárez-Herrera M, Aparicio M, Hernández-Lui F, Hernández A (October 1995). "An Improved Synthesis of Fenbulen". Organic Preparations and Procedures International. 27 (5): 550–552. doi:10.1080/00304949509458497.

[1]

[2]

[3]

[4]

[5]

[6]