Alclofenac

Alclofenac

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	M01AB06 (WHO)
Identifiers
IUPAC name 2-(3-chloro-4-prop-2-enoxyphenyl)acetic acid
CAS Number	22131-79-9
PubChem CID	30951
ChemSpider	28714^Y
UNII	M9CP5H21N8
KEGG	D01252^Y
ChEMBL	ChEMBL94081^Y
CompTox Dashboard (EPA)	DTXSID4020038
ECHA InfoCard	100.040.709
Chemical and physical data
Formula	C11H11ClO3
Molar mass	226.66 g·mol^−1
3D model (JSmol)	Interactive image
SMILES Clc1cc(ccc1OC\C=C)CC(=O)O
InChI InChI=1S/C11H11ClO3/c1-2-5-15-10-4-3-8(6-9(10)12)7-11(13)14/h2-4,6H,1,5,7H2,(H,13,14)^Y Key:ARHWPKZXBHOEEE-UHFFFAOYSA-N^Y
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Alclofenac is a nonsteroidal anti-inflammatory drug (NSAID).

Synthesis

Alclofenac synthesis pathway^[1][2][3]

References

1. Gaviraghi G, Banfi S, Cornelli U, Pinza M, Pifferi G (April 1977). "Synthesis and antiinflammatory activity of 3-chloro-4-cyclopropylmethoxyphenylacetic acid and its alpha-methyl homologue". Il Farmaco; Edizione Scientifica. 32 (4): 286–95. PMID 862882.
2. CA 831040, Gillet C, Buu HN, Lambelin G, "Substituted Phenylacetic Acids and Processes of Preparation Thereof", published 30 December 1969, assigned to Madan Ag 
3. US 3824277, Gillet C, Buu HN, Lambelin G, "4-Allyloxy-3-chloro-phenyl-acetic acid", published 16 July 1974, assigned to Madan Ag