Evacetrapib

Evacetrapib
Names
IUPAC name
Trans-4-({(5S)-5-[{[3,5-bis(trifluoromethyl)phenyl]methyl}(2-methyl-2H-tetrazol-5- yl)amino]-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzazepin-1-yl}methyl) cyclohexanecarboxylic acid
Other names
LY2484595
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.227.032 Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C31H36F6N6O2/c1-18-11-19(2)27-25(12-18)26(5-4-10-42(27)16-20-6-8-22(9-7-20)28(44)45)43(29-38-40-41(3)39-29)17-21-13-23(30(32,33)34)15-24(14-21)31(35,36)37/h11-15,20,22,26H,4-10,16-17H2,1-3H3,(H,44,45)/t20-,22-,26-/m0/s1 checkY
    Key: IHIUGIVXARLYHP-YBXDKENTSA-N checkY
  • InChI=1/C31H36F6N6O2/c1-18-11-19(2)27-25(12-18)26(5-4-10-42(27)16-20-6-8-22(9-7-20)28(44)45)43(29-38-40-41(3)39-29)17-21-13-23(30(32,33)34)15-24(14-21)31(35,36)37/h11-15,20,22,26H,4-10,16-17H2,1-3H3,(H,44,45)/t20-,22-,26-/m0/s1
    Key: IHIUGIVXARLYHP-YBXDKENTBY
  • O=C([C@H]1CC[C@H](CN2CCC[C@H](N(CC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C4=NN(C)N=N4)C5=CC(C)=CC(C)=C52)CC1)O
Properties
C31H36F6N6O2
Molar mass 638.659 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Evacetrapib was a drug under development by Eli Lilly and Company (investigational name LY2484595) that inhibits cholesterylester transfer protein (CETP inhibitor). CETP collects triglycerides from very low-density lipoproteins (VLDL) or low-density lipoproteins (LDL) and exchanges them for cholesteryl esters from high-density lipoproteins (HDL), and vice versa, but primarily increasing high-density lipoprotein and lowering low-density lipoprotein. It is thought that modifying lipoprotein levels modifies the risk of cardiovascular disease.[1] The first CETP inhibitor, torcetrapib, was unsuccessful because it increased levels of the hormone aldosterone and increased blood pressure,[2] which led to excess cardiac events when it was studied.[2] Evacetrapib does not have the same effect.[1] When studied in a small clinical trial in people with elevated LDL and low HDL, significant improvements were noted in their lipid profile.[3]

Evacetrapib evaluation for treatment of high-risk vascular disease was discontinued due to lack of efficacy, as had already happened in the past with two other CETP inhibitors (torcetrapib and dalcetrapib[4]) due to increased deaths and little identifiable cardiovascular benefit (despite substantial increases in HDL). Some hypothesize that CETP inhibitors may still be useful in the treatment of dyslipidemia, though significant caution is warranted.[2] Anacetrapib is the fourth CETP inhibitor being tried for cardiovascular benefit [1]

Trials

ACCELERATE

In a 2014 study in 165 Japanese patients evacetrapib decreased CETP activity alone or in combination with atorvastatin.[5]

Phase III trial was terminated due to futility.[6][7] ACCELERATE studied evacetrapib in participants with high-risk vascular disease (previous myocardial infarction, stroke or peripheral vascular disease, or several cardiovascular risk factors). An interim analysis performed in October 7 led the Data Monitoring Committee to support a recommendation to stop the study as the totality of evidence suggested that evacetrapib was unlikely to be superior to placebo.[8] ACCENTUATE is studying patients with hyperlipidemia or diabetes.[9]

On April 3, 2016 at the American College of Cardiology cardiologists first saw the data for Eli Lilly's ACCELERATE trial of evacetrapib involving 12,000 patients.[10] They were "stunned" by the result which showed there was no benefit from taking evacetrapib—434 participants who took evacetrapib died from "cardiovascular disease, such as a heart attack or a stroke" and 444 participants who took a placebo died.[10] The ACCELERATE trial led by Stephen J. Nicholls who observed,[10]

"“It’s the most mind-boggling question. How can a drug that lowers something that is associated with benefit not show any benefit?"

— Stephen J. Nicholls 2016

References

  1. ^ a b c Cao G, Beyer TP, Zhang Y, et al. (December 2011). "Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure". J. Lipid Res. 52 (12): 2169–76. doi:10.1194/jlr.M018069. PMC 3220285. PMID 21957197.
  2. ^ a b c Joy T, Hegele RA (July 2009). "The end of the road for CETP inhibitors after torcetrapib?". Curr. Opin. Cardiol. 24 (4): 364–71. doi:10.1097/HCO.0b013e32832ac166. PMID 19522058. S2CID 6965741.
  3. ^ Nicholls SJ, Brewer HB, Kastelein JJ, Krueger KA, Wang MD, Shao M, Hu B, McErlean E, Nissen SE (2011). "Effects of the CETP inhibitor evacetrapib administered as monotherapy or in combination with statins on HDL and LDL cholesterol". JAMA. 306 (19): 2099–109. doi:10.1001/jama.2011.1649. PMID 22089718.
  4. ^ Schwartz GG; et al. (Nov 2015). "Effects of dalcetrapib in patients with a recent acute coronary syndrome" (PDF). N Engl J Med. 367 (22): 2089–99. doi:10.1056/NEJMoa1206797. PMID 23126252.
  5. ^ Teramoto, Tamio; Takeuchi, Masakazu; Morisaki, Yoji; Ruotolo, Giacomo; Krueger, Kathryn A. (Jun 15, 2014). "Efficacy, safety, tolerability, and pharmacokinetic profile of evacetrapib administered as monotherapy or in combination with atorvastatin in Japanese patients with dyslipidemia". Am J Cardiol. 113 (12): 2021–9. doi:10.1016/j.amjcard.2014.03.045. PMID 24786356.
  6. ^ "Assessment of Clinical Effects of Cholesteryl Ester Transfer Protein Inhibition With Evacetrapib in Patients at a High Risk for Vascular Outcomes - ACCELERATE".
  7. ^ "A Study of Evacetrapib in High-Risk Vascular Disease (ACCELERATE)".
  8. ^ "Lilly to Discontinue Development of Evacetrapib for High-Risk Atherosclerotic Cardiovascular Disease". Archived from the original on 2015-11-03.
  9. ^ "Study of Evacetrapib (LY2484595) in Participants With High Cholesterol (ACCENTUATE)". 25 September 2019.
  10. ^ a b c Kolata, Gina (3 April 2016). "Dashing Hopes, Study Shows a Cholesterol Drug Had No Effect on Heart Health". New York Times. Retrieved 4 April 2016.

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