Ezetimibe/rosuvastatin, sold under the brand name Ridutrin among others, is a combination medication used to treat high cholesterol.[6][7] In some countries it is sold as a kit or a pack containing two distinct pills.[8][9]
The combination was approved for medical use in the United States in March 2021.[4]
Medical uses
Ezetimibe/rosuvastatin is indicated as an adjunct to diet in people with primary non-familial hyperlipidemia to reduce low-density lipoprotein cholesterol (LDL-C); and alone or as an adjunct to other LDL-C-lowering therapies in people with homozygous familial hypercholesterolemia (HoFH) to reduce LDL-C.[10]
Pharmacology
Ezetimibe/rosuvastatin combines two lipid-lowering therapies.
Ezetimibe inhibits NPC1L1, the transporter that is responsible for absorption of dietary cholesterol from the intestine.[3]
