On 28 April 2018, he refereed Serie A match between Inter Milan and Juventus where some of his decisions was subject of much controversy including failed to show Juventus' Miralem Pjanic a second yellow card. Orsato himself acknowledged the mistake years later.[7]
He also refereed the second leg of the 2021 UEFA Champions League semi-final between Chelsea and Real Madrid.
In 2020, Orsato was awarded by IFFHS as the best referee of that calendar year.[9]
On 20 November 2022, Orsato was appointed as the referee for the opening match of the 2022 FIFA World Cup between hosts Qatar and Ecuador.[10]
On 13 December 2022, Orsato refereed the World Cup semi-final between Argentina and Croatia where he came under fire by Ballon d'Or winner and Croatia captain Luka Modrić as "one of the worst" referees, describing his performance in that game as "a disaster".[11]