Cytidine deaminase

CDA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MQ0
Identifiers
Aliases	CDA, CDD, cytidine deaminase
External IDs	OMIM: 123920; MGI: 1919519; HomoloGene: 1352; GeneCards: CDA; OMA:CDA - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 20,589,086 bp[1] End 20,618,903 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 138,065,735 bp[2] End 138,095,303 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood bone marrow right lobe of liver trabecular bone bone marrow cells testicle rectum skin of leg Top expressed in right kidney duodenum gastrula human kidney intestinal villus jejunum proximal tubule lumbar spinal ganglion facial motor nucleus endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity nucleoside binding cytidine deaminase activity zinc ion binding metal ion binding protein binding catalytic activity identical protein binding hydrolase activity Cellular component cytosol extracellular region secretory granule lumen tertiary granule lumen ficolin-1-rich granule lumen Biological process cytosine metabolic process pyrimidine nucleoside salvage cell surface receptor signaling pathway cytidine deamination negative regulation of cell growth pyrimidine-containing compound salvage negative regulation of nucleotide metabolic process protein homotetramerization neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 978 72269 Ensembl ENSG00000158825 ENSMUSG00000028755 UniProt P32320 P56389 RefSeq (mRNA) NM_001785 NM_028176 RefSeq (protein) NP_001776 NP_082452 Location (UCSC) Chr 1: 20.59 – 20.62 Mb Chr 4: 138.07 – 138.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene.^[5][6][7]

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.^[7] Most cytidine deaminases act on RNA, and the few that act on DNA require ssDNA.^[8]

A related activation-induced (cytidine) deaminase (AID) regulates antibody diversification, especially the process of somatic hypermutation.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

1. GRCh38: Ensembl release 89: ENSG00000158825 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028755 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kühn K, Bertling WM, Emmrich F (January 1993). "Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation". Biochemical and Biophysical Research Communications. 190 (1): 1–7. doi:10.1006/bbrc.1993.1001. PMID 8422236.
6. Demontis S, Terao M, Brivio M, Zanotta S, Bruschi M, Garattini E (December 1998). "Isolation and characterization of the gene coding for human cytidine deaminase". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (3): 323–33. doi:10.1016/s0167-4781(98)00235-8. PMID 9878810.
7. "Entrez Gene: CDA cytidine deaminase".
8. Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR (May 2016). "Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage". Nature. 533 (7603): 420–4. Bibcode:2016Natur.533..420K. doi:10.1038/nature17946. PMC 4873371. PMID 27096365.

Further reading

• Wentworth DF, Wolfenden R (November 1975). "On the interaction of 3,4,5,6-tetrahydrouridine with human liver cytidine deaminase". Biochemistry. 14 (23): 5099–105. doi:10.1021/bi00694a012. PMID 53069.
• Laliberté J, Momparler RL (October 1994). "Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA". Cancer Research. 54 (20): 5401–7. PMID 7923172.
• Saccone S, Besati C, Andreozzi L, Della Valle G, Garattini E, Terao M (August 1994). "Assignment of the human cytidine deaminase (CDA) gene to chromosome 1 band p35-p36.2". Genomics. 22 (3): 661–2. doi:10.1006/geno.1994.1448. PMID 8001985.
• Gran C, Bøyum A, Johansen RF, Løvhaug D, Seeberg EC (June 1998). "Growth inhibition of granulocyte-macrophage colony-forming cells by human cytidine deaminase requires the catalytic function of the protein". Blood. 91 (11): 4127–35. doi:10.1182/blood.V91.11.4127. PMID 9596658.
• Somasekaram A, Jarmuz A, How A, Scott J, Navaratnam N (October 1999). "Intracellular localization of human cytidine deaminase. Identification of a functional nuclear localization signal". The Journal of Biological Chemistry. 274 (40): 28405–12. doi:10.1074/jbc.274.40.28405. PMID 10497201.
• Wistow G, Bernstein SL, Wyatt MK, Behal A, Touchman JW, Bouffard G, et al. (June 2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 171–84. PMID 12107413.
• Taysi S, Polat MF, Sari RA, Bakan E (May 2002). "Serum adenosine deaminase and cytidine deaminase activities in patients with systemic lupus erythematosus". Clinical Chemistry and Laboratory Medicine. 40 (5): 493–5. doi:10.1515/CCLM.2002.085. PMID 12113294. S2CID 32965037.
• Bransteitter R, Pham P, Scharff MD, Goodman MF (April 2003). "Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase". Proceedings of the National Academy of Sciences of the United States of America. 100 (7): 4102–7. Bibcode:2003PNAS..100.4102B. doi:10.1073/pnas.0730835100. PMC 153055. PMID 12651944.
• Sun ZQ, Jiang B, Zhao XS, Bao L, Wu T, Lu XJ, et al. (June 2003). "[Expression of cytidine deaminase mRNA in bone marrow cells from patients with acute leukemia]". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 11 (3): 246–50. PMID 12844405.
• Vincenzetti S, Costanzi S, Cristalli G, Mariani P, Quadrini B, Cammertoni N, Vita A (2003). "Intersubunit interactions in human cytidine deaminase". Nucleosides, Nucleotides & Nucleic Acids. 22 (5–8): 1535–8. doi:10.1081/NCN-120023028. PMID 14565460. S2CID 8626156.
• Costanzi S, Vincenzetti S, Vita A, Lambertucci C, Taffi S, Volpini R, et al. (2003). "Human cytidine deaminase: understanding the catalytic mechanism". Nucleosides, Nucleotides & Nucleic Acids. 22 (5–8): 1539–43. doi:10.1081/NCN-120023029. PMID 14565461. S2CID 6849333.
• Ge Y, Jensen TL, Stout ML, Flatley RM, Grohar PJ, Ravindranath Y, et al. (January 2004). "The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines". Cancer Research. 64 (2): 728–35. doi:10.1158/0008-5472.CAN-03-2456. PMID 14744791.
• Vincenzetti S, De Sanctis G, Costanzi S, Cristalli G, Mariani P, Mei G, et al. (December 2003). "Functional properties of subunit interactions in human cytidine deaminase". Protein Engineering. 16 (12): 1055–61. doi:10.1093/protein/gzg117. PMID 14983087.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (October 2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chung SJ, Fromme JC, Verdine GL (February 2005). "Structure of human cytidine deaminase bound to a potent inhibitor". Journal of Medicinal Chemistry. 48 (3): 658–60. doi:10.1021/jm0496279. PMID 15689149.
• Vincenzetti S, Mariani PL, Cammertoni N, Polzonetti V, Natalini P, Quadrini B, et al. (December 2004). "Isoenzymatic forms of human cytidine deaminase". Protein Engineering, Design & Selection. 17 (12): 871–7. doi:10.1093/protein/gzh101. PMID 15713780.
• Costanzi S, Vincenzetti S, Cristalli G, Vita A (September 2006). "Human cytidine deaminase: a three-dimensional homology model of a tetrameric metallo-enzyme inferred from the crystal structure of a distantly related dimeric homologue". Journal of Molecular Graphics & Modelling. 25 (1): 10–6. doi:10.1016/j.jmgm.2005.10.008. PMID 16303324.

External links

• Overview of all the structural information available in the PDB for UniProt: P32320 (Cytidine deaminase) at the PDBe-KB.