3-dehydroquinate synthase II

3-dehydroquinate synthase II
Identifiers
EC no.	1.4.1.24
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

3-dehydroquinate synthase II (EC 1.4.1.24, DHQ synthase II, MJ1249 (gene), aroB' (gene)) is an enzyme with systematic name 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD⁺ oxidoreductase (deaminating).^[1] This enzyme catalyses the following chemical reaction

2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H₂O + NAD⁺ ${\displaystyle \rightleftharpoons }$ 3-dehydroquinate + NH₃ + NADH + H⁺

The enzyme was isolated from the archaeon Methanocaldococcus jannaschii.

References

1. White RH (June 2004). "L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii". Biochemistry. 43 (23): 7618–27. doi:10.1021/bi0495127. PMID 15182204.

External links

• 3-dehydroquinate+synthase+II at the U.S. National Library of Medicine Medical Subject Headings (MeSH)