Holly was fired for cause on August 31, 2021, and the club named Mario Sanchez, head of the club's youth academy and former collegiate coach, as the interim head coach.[4]
Racing Louisville's group stage matches in the East Division of the 2021 NWSL Challenge Cup were the first competitive matches in club history. The opening match, a 2–2 draw against Orlando Pride, was the club's first at their home ground, Lynn Family Stadium. With two draws and two losses in four group matches, Racing finished at the bottom of East Division in their first Challenge Cup.[6]
Stadium: WakeMed Soccer Park Attendance: Unreported Referee: Matthew Franz Assistant referees: Jeremy Smith, Caleb Fearing Fourth official: Shawn Tehini
Stadium: Providence Park Attendance: Not reported Referee: Samantha Martinez Assistant referees: Salma Perez, Corbyn May Fourth official: Luis Trujillo
Stadium: Lynn Family Stadium Attendance: 5,971 Referee: Laura Rodriguez Assistant referees: Meghan Mullen, Maggie Short Fourth official: Chris Schurfranz
Stadium: Lynn Family Stadium Attendance: 7,310 Referee: Karen Abt Assistant referees: Kali Smith, Noah Matos Fourth official: Katherine McCormick
Note: A penalty kick shoot-out following full time was needed to decide a winner for the match's dual status as a semifinal of the inaugural International Women's Cup. Racing Louisville won the shoot-out 5 - 4.
Racing Louisville hosted and participated in the inaugural The Women's Cup, a four-team competition featuring two sides from the NWSL and two sides from Europe.[8] Racing Louisville and Chicago Red Stars from NWSL were joined by Paris Saint-Germain Féminine and FC Bayern Munich. In the semifinals on August 18, 2021, Racing Louisville drew with Chicago Red Stars and advanced to the Championship match on penalty kicks, where they would face Bayern Munich, who had also advanced past Paris Saint-Germain via penalty shootout. In the Championship match, Racing Louisville fell behind early in the second half before quickly equalizing on a goal by Jorian Baucom, then took the lead on a goal by Yūki Nagasato, only to yield another to Bayern Munich in stoppage time, sending the match to penalties. Racing Louisville prevailed in an 11-round shootout, after backup goalkeeper Katie Lund converted her spot kick and saved the attempt by her counterpart, Laura Benkarth.[9][10]
Racing Louisville did not qualify for the NWSL Playoffs. Playoffs will start on November 6 and will conclude with the NWSL Championship on November 20, to be held at Lynn Family Stadium in Louisville.[11]