The 2021–22 season was the 123rd season in the existence of SC Freiburg and the club's sixth consecutive season in the top flight of German football. In addition to the domestic league, SC Freiburg participated in this season's edition of the DFB-Pokal.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
^ abSince the 2021–22 DFB-Pokal winners, RB Leipzig, qualified for the Champions League based on league position, the Europa League group stage spot was passed to the sixth-placed team, and the Europa Conference League play-off round spot was passed to the seventh-placed team.