The 2021–22 season was A.C. Perugia Calcio's first season back in second division of the Italian football league, the Serie B, and the 117th as a football club.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Source: Lega Serie B (in Italian), Soccerway (in English) Rules for classification: 1) Points; 2) Head-to-head points; 3) Head-to-head goal difference; 4) Goal difference; 5) Goals scored; 6) Draw.[2] Notes:
^ abPerugia finished ahead of Frosinone on head-to-head points: Frosinone 0–0 Perugia, Perugia 3–0 Frosinone.